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Waveguide-based detection system with scanning light source

  • US 10,590,493 B2
  • Filed: 05/17/2018
  • Issued: 03/17/2020
  • Est. Priority Date: 03/10/2006
  • Status: Active Grant
First Claim
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1. A detection system for detecting a biologically active analyte molecule comprising:

  • a substrate comprising one or more excitation waveguides and a plurality of collection waveguides, the one or more excitation waveguides and the plurality of collection waveguides crossing to form an array of intersection regions where an excitation waveguide and a collection waveguide cross and provide optical communication with one intersection region of the array of intersection regions at each crossing, and a plurality of optical sensing sites each in optical communication with the array of intersection regions;

    a scanning light source configured to generate light that is transducable by a sensor associated with at least one of the plurality of optical sensing sites, wherein the one or more excitation waveguides is arranged to propagate the light from the scanning light source to the plurality of optical sensing sites;

    a detector that is in optical communication with one or more of the plurality of collection waveguides; and

    an actuator for spatially translating the light emitted from the scanning light source relative to the substrate such that the light is coupled to and in optical communication with at least one of the one or more excitation waveguides of the substrate at some point along its scanning path.

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