Methods and apparatus for the planning and delivery of radiation treatments

• US 10,595,774 B2
• Filed: 09/18/2017
• Issued: 03/24/2020
• Est. Priority Date: 07/25/2005
• Status: Active Grant

• Current Assignee: Siemens Healthineers International AG
• Original Assignee: Varian Medical Systems Incorporated (Siemens AG)
• Inventors: Otto, Karl
• Primary Examiner(s): Matthews, Christine H
• Assistant Examiner(s): Lannu, Joshua Daryl D
• Application Number:
  US15/707,931
• Publication Number:
  US 20180028113A1
• Time in Patent Office: 918 Days
• CPC Class Codes: A61B 2034/101 Computer-aided simulation of surgical operations
• CPC Class Codes: A61B 34/10 Computer-aided planning, simulation or modelling of surgical operations
• CPC Class Codes: A61B 5/0036 including treatment, e.g., using an implantable medical device, ablating, ventilating
• CPC Class Codes: A61B 5/08 Detecting, measuring or recording devices for evaluating the respiratory organs A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/113 occurring during breathing
• CPC Class Codes: A61N 2005/1032 Genetic optimization methods
• CPC Class Codes: A61N 2005/1034 Monte Carlo type methods; particle tracking
• CPC Class Codes: A61N 2005/1035 Simulated annealing
• CPC Class Codes: A61N 5/103 Treatment planning systems
• CPC Class Codes: A61N 5/1031 using a specific method of dose optimization
• CPC Class Codes: A61N 5/1036 Leaf sequencing algorithms
• CPC Class Codes: A61N 5/1037 taking into account the movement of the target, e.g. 4D-image based planning
• CPC Class Codes: A61N 5/1039 using functional images, e.g. PET or MRI
• CPC Class Codes: A61N 5/1042 with spatial modulation of the radiation beam within the treatment head
• CPC Class Codes: A61N 5/1045 using a multi-leaf collimator, e.g. for intensity modulated radiation therapy or IMRT
• CPC Class Codes: A61N 5/1047 with movement of the radiation head during application of radiation, e.g. for intensity modulated arc therapy or IMAT
• CPC Class Codes: A61N 5/1049 for verifying the position of the patient with respect to the radiation beam
• CPC Class Codes: A61N 5/107 in real time, i.e. during treatment
• CPC Class Codes: A61N 5/1077 Beam delivery systems
• CPC Class Codes: A61N 5/1082 having multiple beam rotation axes

Abstract

Methods and apparatus are provided for planning and delivering radiation treatments by modalities which involve moving a radiation source along a trajectory relative to a subject while delivering radiation to the subject. In some embodiments the radiation source is moved continuously along the trajectory while in some embodiments the radiation source is moved intermittently. Some embodiments involve the optimization of the radiation delivery plan to meet various optimization goals while meeting a number of constraints. For each of a number of control points along a trajectory, a radiation delivery plan may comprise: a set of motion axes parameters, a set of beam shape parameters and a beam intensity.

Claims

1. A method for delivering radiation dose to a target area within a subject, the method comprising:

defining a trajectory comprising relative movement between a treatment radiation source and the subject;

determining a radiation delivery plan;

effecting continuous relative movement between the treatment radiation source and the subject along the trajectory and, during the continuous relative movement between the treatment radiation source and the subject along the trajectory, delivering a treatment radiation beam from the treatment radiation source to the subject according to the radiation delivery plan to impart a dose distribution on the subject;

wherein effecting continuous relative movement between the treatment radiation source and the subject along the trajectory comprises effecting movement of both the radiation source and the subject.

2. A method according to claim 1 wherein the trajectory comprises arbitrary relative movement between the treatment radiation source and the subject.

3. A method according to claim 1 wherein effecting continuous relative movement between the treatment radiation source and the subject along the trajectory comprises varying a relative speed of movement between the treatment radiation source and the subject along the trajectory.

4. A method according to claim 1 wherein effecting continuous relative movement between the radiation source and the subject along the trajectory comprises effecting non-self-overlapping continuous relative movement between the radiation source and the subject.

5. A method according to claim 1 wherein a start of the trajectory and an end of the trajectory comprise the same relative position between the radiation source and the subject and wherein effecting continuous relative movement between the radiation source and the subject along the trajectory comprises otherwise non-self-overlapping continuous relative movement between the radiation source and the subject.

6. A method according to claim 1 wherein effecting continuous relative movement between the radiation source and the subject along the trajectory comprises moving a plurality of motion axes of a radiation delivery apparatus.

7. A method according to claim 1 wherein the trajectory comprising continuous relative movement between the treatment radiation source and the subject comprises a plurality of arcs and wherein each arc of the plurality of arcs is confined to a corresponding plane and at least two of the corresponding planes are non-coplanar.

8. A method according to claim 1 wherein delivering the treatment radiation beam from the treatment radiation source to the subject according to the radiation delivery plan to impart the dose distribution on the subject comprises varying an intensity of the treatment radiation beam over at least a portion of the trajectory and wherein varying the intensity of the treatment radiation beam over at least a portion of the trajectory comprises varying a radiation output rate of the treatment radiation source in accordance with the radiation delivery plan during the relative movement between the treatment radiation source and the subject along the trajectory.

9. A method for delivering radiation dose to a target area within a subject, the method comprising:

defining a trajectory comprising relative movement between a treatment radiation source and the subject;

determining a radiation delivery plan;

effecting relative movement between the treatment radiation source and the subject along the trajectory and, during the relative movement between the treatment radiation source and the subject along the trajectory, delivering a treatment radiation beam from the treatment radiation source to the subject according to the radiation delivery plan to impart a dose distribution on the subject;

wherein delivering the treatment radiation beam from the treatment radiation source to the subject comprises varying an intensity of the treatment radiation beam over at least a portion of the trajectory and wherein varying the intensity of the treatment radiation beam over at least a portion of the trajectory comprises varying a radiation output rate of the treatment radiation source in accordance with the radiation delivery plan during the relative movement between the treatment radiation source and the subject along the trajectory.

10. A method according to claim 9 wherein effecting relative movement between the treatment radiation source and the subject along the trajectory comprises varying a relative speed of movement between the treatment radiation source and the subject along the trajectory.

11. A method according to claim 9 wherein effecting relative movement between the treatment radiation source and the subject along the trajectory comprises effecting movement of both the radiation source and the subject.

12. A method according to claim 9 wherein effecting relative movement between the radiation source and the subject along the trajectory comprises effecting non-self-overlapping relative movement between the radiation source and the subjects.

13. A method according to claim 9 wherein a start of the trajectory and an end of the trajectory comprise the same relative position between the radiation source and the subject and wherein effecting relative movement between the radiation source and the subject along the trajectory comprises otherwise non-self-overlapping relative movement between the radiation source and the subject.

14. A method according to claim 9 wherein effecting relative movement between the radiation source and the subject along the trajectory comprises moving a plurality of motion axes of a radiation delivery apparatus.

15. A method according to claim 9 wherein the trajectory comprising relative movement between the treatment radiation source and the subject comprises a plurality of arcs and wherein each arc of the plurality of arcs is confined to a corresponding plane and at least two of the corresponding planes are non-coplanar.

16. A method for delivering radiation dose to a target area within a subject, the method comprising:

defining a set of one or more optimization goals, the set of one or more optimization goals comprising a desired dose distribution in the subject;

defining an initial trajectory for relative movement between a radiation source and the subject and an initial plurality of control points along the initial trajectory;

iteratively optimizing a simulated dose distribution relative to the set of one or more optimization goals to determine one or more radiation delivery parameters associated with each of the control points;

wherein the one or more radiation delivery parameters comprise a position of the radiation source relative to the subject and wherein iteratively optimizing the simulated dose distribution comprises defining an optimized trajectory fox′

relative movement between the radiation source and the subject based on the one or more radiation delivery parameters; and

effecting relative movement between the treatment radiation source and the subject along the optimized trajectory and, during the relative movement between the treatment radiation source and the subject along the optimized trajectory, delivering a treatment radiation beam from the treatment radiation source to the subject according to the determined radiation delivery to impart a dose distribution on the subject.

17. A method according to claim 16 wherein delivering the treatment radiation beam from the treatment radiation source to the subject according to the one or more radiation delivery parameters to impart the dose distribution on the subject comprises varying an intensity of the treatment radiation beam over at least a portion of the optimized trajectory and wherein varying the intensity of the treatment radiation beam over at least a portion of the optimized trajectory comprises varying a radiation output rate of the treatment radiation source in accordance with the one or more radiation delivery parameters during the relative movement between the treatment radiation source and the subject along the optimized trajectory.

18. A method according to claim 16 wherein effecting relative movement between the treatment radiation source and the subject along the optimized trajectory comprises varying a relative speed of movement between the treatment radiation source and the subject along the trajectory.

19. A method according to claim 16 wherein effecting relative movement between the treatment radiation source and the subject along the optimized trajectory comprises effecting movement of both the radiation source and the subject.