Energy delivery systems and uses thereof

• US 10,603,106 B2
• Filed: 12/18/2017
• Issued: 03/31/2020
• Est. Priority Date: 05/03/2010
• Status: Active Grant

• Current Assignee: Neuwave Medical, Inc. (Johnson & Johnson)
• Original Assignee: Neuwave Medical, Inc. (Johnson & Johnson)
• Inventors: Van der Weide, Daniel Warren, Lee, Jr., Fred T., Brace, Christopher Lee, Schefelker, Richard W., King, Laura G., Thom, Mark, Thiel, Matthew
• Primary Examiner(s): Flory, Christopher A
• Application Number:
  US15/845,785
• Publication Number:
  US 20180125579A1
• Time in Patent Office: 834 Days
• CPC Class Codes: A61B 1/0051 with controlled bending of insertion part
• CPC Class Codes: A61B 17/320068 using mechanical vibrations, e.g. ultrasonic A61B17/22012 takes precedence; dental tooth drilling devices operated by vibration A61C3/03; removing intra-ocular material using mechanical vibrations A61F9/00745
• CPC Class Codes: A61B 18/1487 Trocar-like, i.e. devices producing an enlarged transcutaneous opening
• CPC Class Codes: A61B 18/1815 using microwaves
• CPC Class Codes: A61B 2017/320069 for ablating tissue
• CPC Class Codes: A61B 2017/32007 with suction or vacuum means
• CPC Class Codes: A61B 2018/00023 closed, i.e. without wound contact by the fluid
• CPC Class Codes: A61B 2018/00071 Electrical conductivity
• CPC Class Codes: A61B 2018/00279 deployable
• CPC Class Codes: A61B 2018/00285 Balloons
• CPC Class Codes: A61B 2018/00541 Lung or bronchi
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 2018/00744 Fluid flow
• CPC Class Codes: A61B 2018/00791 Temperature
• CPC Class Codes: A61B 2018/00875 Resistance or impedance
• CPC Class Codes: A61B 2018/0212 using an instrument inserted into a body lumen, e.g. catheter
• CPC Class Codes: A61B 2018/183 characterised by the type of antenna
• CPC Class Codes: A61B 2018/1861 with an instrument inserted into a body lumen or cavity, e.g. a catheter
• CPC Class Codes: A61B 2018/1892 Details of electrical isolations of the antenna
• CPC Class Codes: A61B 2034/2059 Mechanical position encoders
• CPC Class Codes: A61B 2090/374 : NMR or MRI
• CPC Class Codes: A61B 2090/3762 : using computed tomography systems [CT]
• CPC Class Codes: A61M 2025/0004 : having two or more concentrically arranged tubes for forming a concentric catheter system
• CPC Class Codes: A61M 2025/0681 : Systems with catheter and outer tubing, e.g. sheath, sleeve or guide tube
• CPC Class Codes: A61M 25/0021 : characterised by the form of the tubing A61M25/0054 takes precedence
• CPC Class Codes: A61M 25/0105 : Steering means as part of the catheter or advancing means; Markers for positioning systems for detection of markers A61B
• CPC Class Codes: A61M 25/0133 : Tip steering devices
• CPC Class Codes: A61M 25/0136 : Handles therefor
• CPC Class Codes: A61M 25/0147 : with movable mechanical means, e.g. pull wires

Abstract

The present invention relates to comprehensive systems, devices and methods for delivering energy to tissue for a wide variety of applications, including medical procedures (e.g., tissue ablation, resection, cautery, vascular thrombosis, treatment of cardiac arrhythmias and dysrhythmias, electrosurgery, tissue harvest, etc.). In certain embodiments, systems, devices, and methods are provided for delivering energy to difficult to access tissue regions (e.g. peripheral lung tissues), and/or reducing the amount of undesired heat given off during energy delivery.

Claims

1. A system comprising:

a) a primary catheter, wherein said primary catheter comprises a primary lumen;

b) a channel catheter, wherein said channel catheter is configured to fit within said primary lumen, and wherein said channel catheter comprises a channel lumen;

c) a steerable navigation catheter, wherein said steerable navigation catheter is configured to fit within said channel lumen, and wherein said steerable navigation catheter comprises a steerable tip and position sensing element; and

d) a microwave energy delivery device, wherein said microwave energy delivery device is configured to fit within said channel lumen, wherein the microwave energy delivery device comprises an inner conductor and an outer conductor,

the inner conductor comprises a proximal end and a distal end,

the outer conductor comprises a proximal end and a distal end,

the microwave energy delivery device is formed such that the coolant can circulate via the proximal end of the inner conductor, through a cooling channel of the inner conductor, out from a distal end of the inner conductor, via a region between the distal end of the inner conductor and the distal end of the outer conductor, through space which is formed in the outer conductor, and extends from the distal side of the outer conductor to a proximal side of the outer conductor, and via a region between the proximal end of the inner conductor and the proximal end of the outer conductor.

2. The system of claim 1, wherein said primary catheter comprises a bronchoscope.

3. The system of claim 1, further comprising a handle for manipulation of one or more of said primary catheter, said channel catheter, said steerable navigation catheter, and said energy delivery device.

4. The system of claim 1, further comprising a processor capable of operating the components of said system.

5. The system of claim 1, wherein said energy delivery device is capable of delivering microwave energy through said channel catheter.

6. The system of claim 1, wherein:

the microwave energy delivery device is provided with a power rating, and

the microwave energy delivery device delivers an energy that exceeds the power rating.

7. The system of claim 1, wherein the coolant is CO₂.

8. The system of claim 1, wherein the microwave energy delivery device has a sufficient length to extend from an oral cavity of a human subject, through a trachea of the human subject, and to a peripheral lung of the human subject.

9. The system of claim 1, wherein the microwave energy delivery device has a diameter of 2 mm or less, and the microwave energy delivery device is flexible.

10. A method of placing an energy delivery device at a difficult to reach treatment site comprising:

a) providing the system of claim 1, wherein said steerable navigation catheter is within the channel lumen, and said channel catheter is within said primary lumen;

b) inserting said primary catheter into an opening in a subject and directing said primary catheter towards said treatment site until further advance is constrained by the diameter of said primary catheter;

c) advancing said channel catheter beyond the distal end of said primary catheter and extending said channel catheter to said treatment site;

d) securing the distal end of said channel catheter at said treatment site;

e) withdrawing said steerable navigation catheter through said channel lumen and out the proximal end of said channel catheter;

f) inserting said energy delivery device through said channel lumen until the distal end of said energy delivery device reaches said treatment site.

11. The method of claim 10, wherein said difficult to reach treatment site comprises the periphery of the lung.

12. The method of claim 11, wherein said difficult to reach treatment site comprises a peripheral lung nodule.

13. The method of claim 12, wherein said lung nodule is accessed through the bronchial tree.

14. A system comprising:

a) a primary catheter, wherein said primary catheter comprises a primary lumen;

b) a channel catheter, wherein said channel catheter is configured to fit within said primary lumen, and wherein said channel catheter comprises a channel lumen;

c) a steerable navigation catheter, wherein said steerable navigation catheter is configured to fit within said channel lumen, and wherein said steerable navigation catheter comprises a steerable tip and position sensing element; and

d) a microwave energy delivery device, wherein said microwave energy delivery device is configured to fit within said channel lumen, wherein the microwave energy delivery device comprises an inner conductor and an outer conductor,

the inner conductor comprises a proximal end and a distal end,

the outer conductor comprises a proximal end and a distal end,

the microwave energy delivery device is formed such that the coolant can circulate via the proximal end of the inner conductor, through a cooling channel of the inner conductor, out from a distal end of the inner conductor, via a region between the distal end of the inner conductor and the distal end of the outer conductor, through space which is formed in the outer conductor, and extends from the distal side of the outer conductor to a proximal side of the outer conductor, and via a region between the proximal end of the inner conductor and the proximal end of the outer conductor,

the microwave energy delivery device is provided with a power rating, and

the microwave energy delivery device delivers an energy that exceeds the power rating.

15. The system of claim 14, wherein the coolant is CO₂.