Current sensing multiple output current stimulators

• US 10,603,495 B2
• Filed: 05/15/2018
• Issued: 03/31/2020
• Est. Priority Date: 03/15/2013
• Status: Active Grant

• Current Assignee: Alfred E. Mann Foundation For Scientific Research
• Original Assignee: Alfred E. Mann Foundation For Scientific Research
• Inventors: Lee, Edward K.F.
• Primary Examiner(s): Gedeon, Brian T
• Assistant Examiner(s): Edwards, Philip C
• Application Number:
  US15/980,642
• Publication Number:
  US 20190015664A1
• Time in Patent Office: 686 Days
• Field of Search: 607 34, 607 46
• CPC Class Codes: A61N 1/36003 of motor muscles, e.g. for walking assistance
• CPC Class Codes: A61N 1/3605 Implantable neurostimulators for stimulating central or peripheral nerve system
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36125 Details of circuitry or electric components
• CPC Class Codes: A61N 1/36146 specified by the stimulation parameters
• CPC Class Codes: H03K 3/012 Modifications of generator to improve response time or to decrease power consumption
• CPC Class Codes: H03K 3/023 by the use of differential amplifiers or comparators, with internal or external positive feedback

Abstract

A multiple output current stimulator circuit with fast turn on time is described. At least one pair of input side and output side transistors is arranged in a current mirror connected to a supply transistor by cascode coupling. The output side transistor supplies stimulation current to an electrode in contact with tissue. An operational amplifier connected to a reference voltage and to the output side transistor drives the supply transistor to maintain the voltage at the output side transistor equal to the reference voltage. The at least one pair of transistors includes multiple pairs of transistors whose output side transistors drive respective electrodes with stimulation currents. The stimulator determines the initiation and duration of stimulation current pulses supplied to each electrode. At circuit activation, large currents are generated which discharge capacitances in the output side transistors causing rapid output side transistor turn on.

Claims

1. A method of providing stimulation comprising:

implanting a pulse generator configured to generate one or several electrical pulses in a portion of a body, the pulse generator comprising a stimulator circuit, wherein the stimulator circuit comprises a supply transistor having a gate connected to a differential amplifier and an output connected to a gate of each of a plurality of output transistors;

implanting a lead within the portion of the body, wherein the lead comprises one or more electrodes;

positioning the one or more electrodes of the lead proximate to a nerve; and

connecting the lead to the pulse generator.

2. The method of providing stimulation of claim 1, further comprising generating an electrical pulse with the pulse generator;

and conducting the electrical pulse to the nerve with the lead.

3. The method of providing stimulation of claim 1, wherein the stimulator circuit further comprises a current source.

4. The method of providing stimulation of claim 3, wherein the pulse generator further comprises a switching control circuit.

5. The method of providing stimulation of claim 4, wherein the switching control circuit is configured to control a plurality of switches, each of the plurality of switches configured to selectively couple the output of the supply transistor to at least one of the one or several gates of the one or several output transistors.

6. The method of providing stimulation of claim 5, wherein the pulse generator comprises a stimulation controller.

7. The method of providing stimulation of claim 6, further comprising generating a turn on signal with the stimulation controller.

8. The method of providing stimulation of claim 7, wherein an electrical pulse of the one or several electrical pulses is generated in response to receipt of the turn on signal.

9. The method of providing stimulation of claim 8, wherein generating the one or several electrical pulses comprises:

driving the supply transistor to produce a turn on time of the stimulator circuit of less than 5 μ

s for the electrical pulse having a current of less than 50 mA.

10. The method of providing stimulation of claim 8, wherein generating the one or several electrical pulses comprises:

driving the supply transistor to produce a turn on time of the stimulator circuit of less than 2 μ

s for the electrical pulse having a current between 200 μ

A and 25 mA.

11. The method of providing stimulation of claim 8, wherein the one of the one or several electrical pulses has a pulse width of 50 μ

s.

12. The method of providing stimulation of claim 8, wherein the differential amplifier comprises an output arranged to drive the supply transistor as a function of a difference between a reference voltage and a common sensing voltage.

13. The method of providing stimulation of claim 12, wherein the switching control circuit controls the reference voltage such that the reference voltage is provided upon activation of at least one switch of the plurality of switches to thereby discharge capacitances related to an output side transistor corresponding to the at least one activated switch.

14. The method of providing stimulation of claim 13, wherein upon providing the reference voltage, the differential amplifier drives the supply transistor so as to discharge capacitances related to the output side transistor corresponding to the at least one activated switch.

15. A method of providing stimulation comprising:

implanting a pulse generator configured to generate one or several electrical pulses in a portion of a body, the pulse generator comprising a switching control circuit and a stimulator circuit, wherein the stimulator circuit comprises a supply transistor having an output connected to one or several gates of one or several output transistors, wherein the switching control circuit is configured to control a plurality of switches, each of the plurality of switches configured to selectively couple the output of the supply transistor to at least one of the one or several gates of the one or several output transistors;

implanting a lead within the portion of the body, wherein the lead comprises one or more electrodes;

positioning the one or more electrodes of the lead proximate to a nerve;

connecting the lead to the pulse generator;

receiving switch control signals; and

selectively coupling the output of the supply transistor to at least one of the one or several gates of the one or several output transistor according to the switch control signals.

16. A method of providing stimulation comprising:

implanting a pulse generator configured to generate one or several electrical pulses in a portion of a body, the pulse generator comprising at least one input side transistor;

at least one output side transistor, a switching control circuit, and a stimulator circuit, wherein the stimulator circuit comprises a supply transistor having an output connected to one or several gates of one or several output transistors, wherein the switching control circuit is configured to control a plurality of switches, each of the plurality of switches configured to selectively couple the output of the supply transistor to at least one of the one or several gates of the one or several output transistors;

implanting a lead within the portion of the body, wherein the lead comprises one or more electrodes;

positioning the one or more electrodes of the lead proximate to a nerve;

connecting the lead to the pulse generator.

17. The method of providing stimulation of claim 16, wherein the output side transistor is current mirror coupled to the at least one input side transistor, and wherein the at least one output side transistor has a current output terminal for providing an output current.