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Low-energy defibrillation with nanosecond pulsed electric fields

  • US 10,603,503 B2
  • Filed: 03/02/2016
  • Issued: 03/31/2020
  • Est. Priority Date: 03/03/2015
  • Status: Active Grant
First Claim
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1. A method of defibrillation of a heart comprising:

  • using an external system comprising a nanosecond pulsed electric field (nsPEF) generator and electrodes; and

    ,delivering electrical stimulation to terminate fibrillation in the heart experiencing the fibrillation, the electrical stimulation having an electric field sufficient to restore normal electrical activity of the heart but with a reduced defibrillation energy up to 10 times relative to conventional defibrillation, while avoiding ablating heart tissue and without substantial permanent changes in either one or both of action potential duration or diastolic interval,wherein the electrical stimulation comprising at least one or more electrical pulses having a pulse duration from about 1 nanosecond to about 1,000 nanoseconds, and further having pulse amplitudes ranging from about 0.01 kV to about 100 kV.

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