Filamentary devices for treatment of vascular defects

• US 10,610,231 B2
• Filed: 07/21/2017
• Issued: 04/07/2020
• Est. Priority Date: 05/02/2008
• Status: Active Grant

• Current Assignee: Microvention Incorporated (Terumo Corporation)
• Original Assignee: Sequent Medical, Inc. (Terumo Corporation)
• Inventors: Marchand, Philippe, Cox, Brian J., Rosenbluth, Robert F.
• Primary Examiner(s): Weisberg, Amy R
• Application Number:
  US15/656,879
• Publication Number:
  US 20180000489A1
• Time in Patent Office: 991 Days
• Field of Search: 606157, 606200
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12113 within an aneurysm
• CPC Class Codes: A61B 17/12118 for positioning in conjunction with a stent
• CPC Class Codes: A61B 17/12145 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/12177 comprising additional materials, e.g. thrombogenic, having filaments, having fibers or being coated
• CPC Class Codes: A61B 17/1219 expandable in contact with liquids
• CPC Class Codes: A61B 2017/00526 Methods of manufacturing
• CPC Class Codes: A61B 2017/00867 shape memory effect for prostheses A61F2210/0014
• CPC Class Codes: A61B 2017/12054 Details concerning the detachment of the occluding device from the introduction device
• CPC Class Codes: A61B 2017/12068 detachable by heat
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 29/02 Dilators made of swellable material balloon catheters for angioplasty A61M25/104

Abstract

Methods for treatment of a cerebral aneurysm within a cerebral vasculature of a patient are described. A microcatheter and a device for treatment of the aneurysm are provided. The device is a self-expanding resilient permeable shell having a plurality of elongate resilient filaments with a woven structure. The plurality of filaments includes small and large filaments. The filaments are bundled and secured to each other at a proximal end. A ratio of the total cross-sectional area of small filaments to the total cross-sectional area of large filaments may be between 0.56 and 1.89. The distal end of the microcatheter is advanced to a region of interest within a cerebral artery. The device is advanced through the lumen and out of the distal end of the microcatheter such that the permeable shell deploys and expands within the cerebral aneurysm. The microcatheter is then withdrawn from the cerebral artery.

Claims

1. A method of treating a cerebral aneurysm within a cerebral vasculature of a patient, comprising the steps of:

providing a microcatheter having a proximal end, a distal end, and a lumen therebetween;

providing a device for treatment of an aneurysm within a patient'"'"'s vasculature, comprising;

a self-expanding resilient permeable shell having a proximal end, a distal end, a longitudinal axis and further comprising;

a plurality of elongate resilient filaments with a woven structure, wherein the plurality of filaments includes small filaments and large filaments, wherein the small filaments have a transverse dimension smaller than the transverse dimension of the large filaments, the woven structure having a radially constrained elongated state configured for delivery within a microcatheter with the thin woven filaments extending longitudinally from the proximal end to the distal end radially adjacent each other along a length of the filaments, wherein the filaments are bundled and secured to each other at a proximal end, wherein a ratio of the total cross-sectional area of small filaments to the total cross-sectional area of large filaments is between 0.56 and 1.89, and

advancing the distal end of the microcatheter to a region of interest within a cerebral artery;

advancing the device through the lumen and out of the distal end of the microcatheter such that the permeable shell deploys within the cerebral aneurysm, wherein the permeable shell expands to an expanded state within the cerebral aneurysm, the expanded relaxed state having a longitudinally shortened configuration relative to the radially constrained state; and

withdrawing the microcatheter from the cerebral artery, wherein the permeable shell is the only implant delivered into the cerebral aneurysm through the microcatheter before the microcatheter is withdrawn.

2. The method of claim 1, wherein the permeable shell forms a generally spherical shape when in the expanded relaxed state.

3. The method of claim 1, wherein the permeable shell forms a generally ovoid shape when in the expanded relaxed state.

4. The method of claim 1, wherein the permeable shell forms a generally globular shape when in the expanded relaxed state.

5. The method of claim 1, wherein the woven structure is adapted to reside within the aneurysm.

6. The method of claim 5, wherein the device is adapted to span the neck of the aneurysm.

7. The method of claim 1, wherein, after implantation, no part of the device extends over the aneurysm neck outside of the dome.

8. The method of claim 1, wherein the smaller filaments have a transverse diameter of about 0.015 mm to about 0.05 mm.

9. The method of claim 1, wherein the larger filaments have a transverse diameter of about 0.04 mm to about 0.1 mm.

10. The method of claim 1, wherein the filaments are bundled and secured to each other at a distal end.

11. The method of claim 1, wherein the ratio of the total cross-sectional area of small filaments to the total cross-sectional area of large filaments is between 1.21 and 1.89.

12. The method of claim 1, wherein the ratio of the total cross-sectional area of small filaments to the total cross-sectional area of large filaments is between 1.06 and 1.89.