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Apparatus and method for promoting angiogenesis in ischemic tissue

  • US 10,610,669 B2
  • Filed: 03/16/2016
  • Issued: 04/07/2020
  • Est. Priority Date: 03/16/2016
  • Status: Active Grant
First Claim
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1. A method of promoting angiogenesis in an ischemic area of a patient body, comprising:

  • accessing a subintimal space between an adventitial layer and an intimal layer of a vascular wall of an occluded blood vessel having a vessel lumen, the subintimal space having a surface;

    providing a biologics delivery device comprising a catheter having a proximal end, a distal region having a distal end, a lumen extending therebetween, a catheter shaft, and a plurality of through-wall apertures in the catheter shaft along a longitudinal axis of the distal region of the catheter in fluid communication with the proximal end and the lumen, and an expandable member disposed over the plurality of through-wall apertures and configured to transition between a collapsed state and an expanded state;

    introducing the distal end of the biologics delivery device from the vessel lumen through the intimal layer and into the subintimal space such that the expandable member is positioned in the subintimal space in the collapsed state;

    transitioning the expandable member positioned in the subintimal space from the collapsed state to the expanded state to contact and support the surface of the subintimal space; and

    while the expandable member is positioned in the subintimal space, delivering a biologic through the plurality of through-wall apertures of the biologics delivery device between the catheter and the expandable member, so that the biologic is distributed substantially uniformly along the distal region.

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