Isoindoline compositions and methods for treating neurodegenerative disease
First Claim
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1. A method of treating Alzheimer'"'"'s disease comprising administering to a subject having said disease a total daily dose of 10 to 2000 mg, of a compound of the Formula:
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Abstract
Isoindoline sigma-2 receptor antagonist compounds, pharmaceutical compositions comprising such compounds, and methods for inhibiting Abeta-associated synapse loss or synaptic dysfunction in neuronal cells, modulating an Abeta-associated membrane trafficking change in neuronal cells, and treating cognitive decline associated with Abeta pathology are provided.
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22 Claims
- 1. A method of treating Alzheimer'"'"'s disease comprising administering to a subject having said disease a total daily dose of 10 to 2000 mg, of a compound of the Formula:
- 12. A method of treating Alzheimer'"'"'s disease comprising administering to a subject having said disease a pharmaceutical composition comprising a compound of the Formula:
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