Remotely controllable lens device

• US 10,613,356 B2
• Filed: 09/09/2014
• Issued: 04/07/2020
• Est. Priority Date: 09/09/2013
• Status: Active Grant

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.), PHI Biomed Co., Ltd.
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Yun, Seok-Hyun, Kamrani, Ehsan, Hahn, Sei Kwang, Kim, Hyemin, Keum, Dohee, Lee, Keon Jae, Joo, Choun-Ki
• Primary Examiner(s): Collins, Darryl J
• Application Number:
  US14/917,324
• Publication Number:
  US 20160223842A1
• Time in Patent Office: 2,037 Days
• Field of Search: 35115901, 35115902, 35115903, 35115939, 3511594
• CPC Class Codes: A61F 2/16 Intraocular lenses
• CPC Class Codes: A61F 2/1624 having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
• CPC Class Codes: A61F 2250/0001 Means for transferring electromagnetic energy to implants
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: G02C 11/10 Electronic devices other than hearing aids
• CPC Class Codes: G02C 7/04 Contact lenses for the eyes disinfection or sterilisation of contact lenses A61L12/00

Abstract

One aspect of the present disclosure relates to a remotely controllable lens device. The lens device can include a lens material and a circuit physically coupled to the lens material. The circuit can be configured to be powered based on an energy signal from a power source to perform a function (e.g., release of drug, generation of electromagnetic radiation, detection of electromagnetic radiation, and/or control of an optical refractive property). For example, the power source can be an external power source and/or an auto-powered source. The external power source can be, for example, a power source that utilizes synchronized magnetic flux phase coupling (e.g., WiTricity). The auto-powered source can be provided on-site (e.g., on-chip) using a harvesting system (e.g., solar-cell, photo-cell, piezoelectric, etc.)

Claims

1. A lens device for drug delivery comprising:

a lens material; and

a circuit physically coupled to the lens material and configured to be powered based on an energy signal from a power source to perform a function, wherein the power source comprises an auto-power source and an external power source that utilizes synchronized magnetic flux phase coupling, the external power source is a WiTricity power source, the circuit includes an antenna for wireless power transfer for gathering power for auto-powering the circuit and an antenna for communication, and the lens device includes a drug delivery system consisting of drug-coated gold nanoparticles attached to one of said antenna and/or drug reservoirs coated with an Au membrane.

2. The lens device of claim 1, wherein at least one of the auto-power source delivers power from about 50 micro-Watts (.mu.W) to 1000 micro-Watts (.mu.W) and the external power source that utilizes synchronized magnetic flux phase coupling delivers power greater than 5000 micro-Watts (.mu.W) at a distance of at least 1 centimeter (cm) and greater than 400 micro-Watts (.mu.W) at a distance of at least 2 centimeters (cm).

3. The lens device of claim 1, wherein the auto-power source comprises a power harvesting system located on the circuit comprising at least one of a solar-cell, a photo-cell, and a piezoelectric device.

4. The lens device of claim 1, wherein the external power source that utilizes synchronized magnetic flux phase coupling utilizes a resonance frequency from 100 kHz to 10 MHz.

5. The lens device of claim 1, wherein the function comprises at least one of a release of a drug from the lens device, a generation of a first electromagnetic radiation from the lens device, a detection of a second electromagnetic radiation at the lens device, and a control of an optical refractive property of the lens device.

6. The lens device of claim 5, wherein the optical refractive property comprises at least one of the focal length of the lens, an optical transmission, and an attenuation.

7. The lens device of claim 5, wherein the function further comprises at least one of a detection of a molecule, a detection of a mechanical property, a detection of a force, and a collimation of electromagnetic radiation.

8. The lens device of claim 1, wherein the lens device is configured as an intraocular lens device or a contact lens device.

9. The lens device of claim 1, wherein the circuit is configured to at least one of transmit a signal via a wireless link to a computing device based on the function and receive a signal from a computing device via the wireless link related to the function.

10. The lens device of claim 1, wherein the power source further comprises at least one of a radio frequency power source in a frequency from 2.4 giga-Hertz (GHz) to 5 giga-Hertz (GHz) and an electrical power source.

11. The lens device of claim 1, wherein the lens material comprises a soft polymeric material.

12. The lens device of claim 11, wherein the soft polymeric material is porous.

13. The lens device of claim 12, wherein the function comprises a controlled release of a drug from the lens device or an on-demand release of the drug from the lens device based on a detection of at least one molecule.

14. A system for drug delivery comprising:

a lens device configured as a contact lens device or an intraocular lens device, comprising;

a lens material; and

a circuit physically coupled to the lens material and configured to perform a function; and

a power source configured to transmit an energy signal that powers the circuit, wherein the power source comprises an auto-power source and a power source that utilizes synchronized magnetic flux phase coupling, the external power source is a WiTricity power source, the circuit includes an antenna for wireless power transfer for gathering power for auto-powering the circuit and an antenna for communication, and the lens device includes a drug delivery system consisting of drug-coated gold nanoparticles attached to one of said antenna and/or drug reservoirs coated with an Au membrane.

15. The system of claim 14, wherein the energy signal comprises at least one of an electrical signal, an electro-magnetic signal, and a magnetic signal.

16. The system of claim 14, wherein the power source further comprises at least one of a radio frequency power source and an electrical power source.

17. The system of claim 14, wherein the function comprises at least one of a release of drug from the lens device, a generation of a first electromagnetic radiation from the lens device, a detection of a second electromagnetic radiation at the lens device, and a control of an optical refractive property of the lens device.

18. The system of claim 17, wherein the function further comprises at least one of a detection of a second molecule, a detection of a mechanical property, and a collimation of electromagnetic radiation.

19. The system of claim 14, wherein the circuit is configured to communicate wirelessly with a computing device.

20. A method for drug delivery comprising the steps of:

receiving an energy signal at a circuit physically coupled to a lens device from a power source; and

powering the circuit based on the energy signal; and

performing a function at the circuit, wherein the power source comprises of an auto-powered source and a power source that utilizes synchronized magnetic flux phase coupling, the external power source is a WiTricity power source, the circuit includes an antenna for wireless power transfer for gathering power for auto-powering the circuit and an antenna for communication, and the lens device includes a drug delivery system consisting of drug-coated gold nanoparticles attached to one of said antenna and/or drug reservoirs coated with an Au membrane.

21. The method of claim 20, wherein the function comprises releasing a drug from the lens device.

22. The method of claim 20, wherein the function comprises generating electromagnetic radiation from the lens device.

23. The method of claim 20, wherein the function comprises detecting electromagnetic radiation at the lens device.

24. The method of claim 20, wherein the function comprises controlling an optical refractive property of the lens device.

25. The lens device of claim 24, wherein the optical refractive property comprises at least one of the focal length of the lens device, an optical transmission of the lens device, and an attenuation of the lens device.