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Pharmaceutical composition and method of manufacturing

  • US 10,624,940 B2
  • Filed: 03/20/2019
  • Issued: 04/21/2020
  • Est. Priority Date: 04/17/2014
  • Status: Active Grant
First Claim
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1. A process for obtaining a first and second concentrate of Cannabis sativa, Cannabis indica, or a combination thereof, the process comprising:

  • (a) contacting Cannabis sativa, Cannabis indica, or a combination thereof with a supercritical fluid solvent system comprising carbon dioxide, at a pressure of about 750 to about 3,000 psi, and at a temperature of about −

    20°

    C. to about 70°

    C., to provide an extract of Cannabis sativa, Cannabis indica, or a combination thereof; and

    (b) removing the supercritical fluid solvent system comprising carbon dioxide from the extract of Cannabis sativa, Cannabis indica, or a combination thereof;

    wherein,the contacting in (a) of the Cannabis sativa, Cannabis indica, or a combination thereof with the supercritical fluid solvent system comprising carbon dioxide and the removing in (b) of the supercritical fluid solvent system comprising carbon dioxide, is carried out two or more times, such that the process is a fractional supercritical fluid extraction comprising carbon dioxide;

    the first fractional supercritical fluid extraction comprising carbon dioxide is carried out such that contacting of the Cannabis sativa, Cannabis indica, or a combination thereof provides a first concentrate; and

    the second fractional supercritical fluid extraction comprising carbon dioxide is carried out such that contacting of the Cannabis sativa, Cannabis indica, or a combination thereof provides a second concentrate;

    if the first concentrate is enriched with tetrahydrocannabinol then the second concentrate is enriched with cannabidiol;

    if the first concentrate is enriched with cannabidiol then the second concentrate is enriched with tetrahydrocannabinol;

    each of the first and the second fractional supercritical fluid extractions comprising carbon dioxide are carried out at a pressure of about 750 to about 3,000 psi, a temperature of about −

    20°

    C. to about 70°

    C., and for a period of time of about 1 to about 8 hours, provided the first and the second fractional supercritical fluid extractions are carried out;

    (i) at a different temperature, (ii) at a different pressure, (iii) with a different solvent system comprising carbon dioxide, or (iv) a combination thereof; and

    one of the fractional supercritical fluid extractions comprising carbon dioxide is carried out at a temperature of at least 30°

    C.

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