Implant-based repair of osteochondral defects
First Claim
1. A hydrogel implant comprising three or more hydrogel zones, wherein each hydrogel zone exhibits distinct tunable chemical and/or physical properties relative to one another and exhibits interpenetration between the adjacent hydrogel zones, and wherein the hydrogel zones comprise an inorganic polymer and an organic polymer wherein the inorganic polymer is methacrylated star polydimethylsiloxane and the organic polymer is diacrylated poly(ethylene glycol).
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention is directed to a unique technology for preparing a growth-factor free, cylindrical, hydrogel implant that has multiple (three or more) longitudinal hydrogel zones with varying chemical and physical properties. The implant may be wholly made of hydrogels or the hydrogels may be associated with cells, such as mesenchymal stem cells (MSCs).
4 Citations
20 Claims
- 1. A hydrogel implant comprising three or more hydrogel zones, wherein each hydrogel zone exhibits distinct tunable chemical and/or physical properties relative to one another and exhibits interpenetration between the adjacent hydrogel zones, and wherein the hydrogel zones comprise an inorganic polymer and an organic polymer wherein the inorganic polymer is methacrylated star polydimethylsiloxane and the organic polymer is diacrylated poly(ethylene glycol).
Specification