Blister package for pharmaceutical cartridges

• US 10,625,034 B2
• Filed: 12/03/2014
• Issued: 04/21/2020
• Est. Priority Date: 04/01/2011
• Status: Active Grant

• Current Assignee: Mannkind Corporation
• Original Assignee: Mannkind Corporation
• Inventors: Bergey, Michael S.
• Primary Examiner(s): Cheung, Chun Hoi
• Application Number:
  US14/559,735
• Publication Number:
  US 20150108023A1
• Time in Patent Office: 1,966 Days
• Field of Search: 206528-540
• CPC Class Codes: A61J 1/035 Blister-type containers blisters in general B65D75/36
• CPC Class Codes: A61M 15/0045 using multiple prepacked dosages on a same carrier, e.g. blisters
• CPC Class Codes: A61M 15/0048 the dosages being arranged in a plane, e.g. on diskettes
• CPC Class Codes: A61M 15/0065 Inhalators with dosage or measuring devices A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52
• CPC Class Codes: A61M 2207/00 Methods of manufacture, assembly or production
• CPC Class Codes: B29C 51/14 using multilayered preforms or sheets
• CPC Class Codes: B29K 2027/06 PVC, i.e. polyvinylchloride
• CPC Class Codes: B29K 2027/12 containing fluorine
• CPC Class Codes: B29K 2105/256 Sheets, plates, blanks or films
• CPC Class Codes: B29L 2009/00 Layered products
• CPC Class Codes: B29L 2031/712 Containers; Packaging elements or accessories, Packages closures therefor B29L2031/56; ink or toner cartridges B29L2031/7678; squeeze tubes B29L2023/20; suitcases B29L2031/7418
• CPC Class Codes: B65B 11/52 one sheet being rendered plastic, e.g. by heating, and forced by fluid pressure, e.g. vacuum, into engagement with the other sheet and contents, e.g. skin- , blister-, or bubble- packaging
• CPC Class Codes: B65B 2220/14 Adding more than one type of material or article to the same package
• CPC Class Codes: B65B 47/02 with means for heating the material prior to forming
• CPC Class Codes: B65B 51/10 Applying or generating heat or pressure or combinations thereof welding of plastics per se B29C65/02; closing plastic tube ends in general B29C57/10
• CPC Class Codes: B65B 9/045 for single articles, e.g. tablets
• CPC Class Codes: B65D 11/20 Details of walls made of plastics material
• CPC Class Codes: B65D 75/327 and forming several compartments
• CPC Class Codes: B65D 83/0463 formed in a band or a blisterweb, inserted in a dispensing device or container

Abstract

A blister packaging for a pharmaceutical cartridge or capsule and methods of forming same are disclosed.

Claims

1. A package comprising:

a blistered base sheet including two or more horizontal rows of interconnected cavities wherein the two or more horizontal rows are situated vertically and at the same orientation, wherein each interconnected cavity includes two or more cavities wherein each of the cavities includes a cartridge that includes an injection molded cartridge lid and an injection molded cartridge container that is movable relative to the injection molded cartridge lid, wherein each of the cavities includes a dome structure holding the injection molded cartridge container and a shelf holding and touching the injection molded cartridge lid, and

wherein the one or more cartridges include a pharmaceutical formulation.

2. The package of claim 1, wherein the pharmaceutical formulation comprises an active ingredient and a diketopiperazine.

3. The package of claim 2, wherein the active ingredient selected from the group consisting of insulin, glucagon like peptide 1, glucagon, oxytocin, oxyntomodulin, peptide YY, sumatriptan, a peptidyl peptidase IV inhibitor, parathyroid hormone, a neurotransmitter agonist, a neurotransmitter antagonist molecule, deoxyribonuclease I, active fragments thereof, analogs thereof, or a combination thereof.

4. The package of claim 2, wherein the diketopiperazine is bis-3,6-(N-fumaryl-4-aminobutyl)-2,5-diketo-diketopiperazine.

5. The package of claim 2, wherein the diketopiperazine is

6. The package of claim 1, wherein the injection molded cartridge lid extends over the injection molded cartridge container.

7. The package of claim 2, wherein the active ingredient is a peptide, protein, a small molecule or a nucleic acid.

8. The package of claim 2, wherein the active ingredient is a neurotransmitter agonist or a neurotransmitter antagonist molecule.

9. The package of claim 2, wherein the active ingredient is insulin.

10. The package of claim 2, wherein the active ingredient is glucagon like peptide 1.

11. The package of claim 2, wherein the active ingredient is glucagon.

12. The package of claim 2, wherein the active ingredient is at least one of oxytocin, oxyntomodulin, and peptide YY.

13. The package of claim 12, wherein the active ingredient is oxytocin.

14. The package of claim 12, wherein the active ingredient is oxyntomodulin.

15. The package of claim 12, wherein the active ingredient is peptide YY.

16. The package of claim 1, wherein the blistered base sheet comprises at least three layers selected from polyvinyl chloride and polychlorotrifluoroethylene.

17. The package of claim 16, wherein the polychlorotrifluoroethylene layer forms the middle layer of the blistered base sheet having a thickness of about 230 μ

m to about 720 μ

m in thickness.

18. The package of claim 1, further comprising a lid.

19. The package of claim 18, wherein the lid comprises a foil comprising one or more layers selected from aluminum, plastic polymer or co-polymer.

20. The package of claim 18, wherein the lid has a thickness of about 10 μ

m to 75 μ

m or a thickness greater than 100 μ

m.

21. The package of claim 1, wherein the injection molded cartridge container is locked to the injection molded cartridge lid.

22. The package of claim 1, wherein the pharmaceutical formulation is a dry powder.

23. The package of claim 1, wherein the injection molded cartridge container is movable translationally relative to the injection molded cartridge lid.

24. The package of claim 1 further including a perforation between each of the two or more rows of interconnected cavities.