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Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples

DC
  • US 10,625,262 B2
  • Filed: 11/27/2019
  • Issued: 04/21/2020
  • Est. Priority Date: 07/13/2007
  • Status: Active Grant
First Claim
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1. A system for processing a plurality of nucleic acid-containing samples, the system comprising:

  • a first module configured to extract nucleic acids from the plurality of nucleic acid-containing samples, the first module comprising;

    a plurality of sample tubes in the first module, each sample tube configured to accept a nucleic acid-containing sample of the plurality of nucleic-acid containing samples,a plurality of process chambers in the first module, wherein a process chamber of the plurality of process chambers is spatially separate from, and corresponds to, a sample tube of the plurality of sample tubes, the plurality of process chambers maintained at a same height relative to one another in the first module,a waste chamber in the first module, the waste chamber corresponding to a process chamber of the plurality of process chambers in the first module,a magnetic separator configured to apply a magnetic force to at least one process chamber of the plurality of process chambers in the first module;

    a heater assembly configured to heat at least one process chamber of the plurality of process chambers in the first module;

    a second module configured to receive nucleic acids extracted from the plurality of nucleic acid-containing samples, the second module comprising;

    a plurality of receptacles comprising PCR reagents, wherein a receptacle of the plurality of receptacles is configured to receive nucleic acid extracted from a sample of the plurality of nucleic acid-containing samples; and

    a liquid dispenser configured to dispense or withdraw liquid from the plurality of sample tubes and dispense or withdraw liquid from the plurality of receptacles comprising PCR reagents.

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