Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
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1. A system for processing a plurality of nucleic acid-containing samples, the system comprising:
- a first module configured to extract nucleic acids from the plurality of nucleic acid-containing samples, the first module comprising;
a plurality of sample tubes in the first module, each sample tube configured to accept a nucleic acid-containing sample of the plurality of nucleic-acid containing samples,a plurality of process chambers in the first module, wherein a process chamber of the plurality of process chambers is spatially separate from, and corresponds to, a sample tube of the plurality of sample tubes, the plurality of process chambers maintained at a same height relative to one another in the first module,a waste chamber in the first module, the waste chamber corresponding to a process chamber of the plurality of process chambers in the first module,a magnetic separator configured to apply a magnetic force to at least one process chamber of the plurality of process chambers in the first module;
a heater assembly configured to heat at least one process chamber of the plurality of process chambers in the first module;
a second module configured to receive nucleic acids extracted from the plurality of nucleic acid-containing samples, the second module comprising;
a plurality of receptacles comprising PCR reagents, wherein a receptacle of the plurality of receptacles is configured to receive nucleic acid extracted from a sample of the plurality of nucleic acid-containing samples; and
a liquid dispenser configured to dispense or withdraw liquid from the plurality of sample tubes and dispense or withdraw liquid from the plurality of receptacles comprising PCR reagents.
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Abstract
The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within microfluidic channels, and detect those nucleotides.
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24 Claims
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1. A system for processing a plurality of nucleic acid-containing samples, the system comprising:
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a first module configured to extract nucleic acids from the plurality of nucleic acid-containing samples, the first module comprising; a plurality of sample tubes in the first module, each sample tube configured to accept a nucleic acid-containing sample of the plurality of nucleic-acid containing samples, a plurality of process chambers in the first module, wherein a process chamber of the plurality of process chambers is spatially separate from, and corresponds to, a sample tube of the plurality of sample tubes, the plurality of process chambers maintained at a same height relative to one another in the first module, a waste chamber in the first module, the waste chamber corresponding to a process chamber of the plurality of process chambers in the first module, a magnetic separator configured to apply a magnetic force to at least one process chamber of the plurality of process chambers in the first module; a heater assembly configured to heat at least one process chamber of the plurality of process chambers in the first module; a second module configured to receive nucleic acids extracted from the plurality of nucleic acid-containing samples, the second module comprising; a plurality of receptacles comprising PCR reagents, wherein a receptacle of the plurality of receptacles is configured to receive nucleic acid extracted from a sample of the plurality of nucleic acid-containing samples; and a liquid dispenser configured to dispense or withdraw liquid from the plurality of sample tubes and dispense or withdraw liquid from the plurality of receptacles comprising PCR reagents. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification