Sheet packs and methods for treating skin

• US 10,631,616 B2
• Filed: 11/15/2017
• Issued: 04/28/2020
• Est. Priority Date: 07/28/2015
• Status: Active Grant

• Current Assignee: ELC Management LLC (The Estee Lauder Companies Inc.)
• Original Assignee: ELC Management LLC (The Estee Lauder Companies Inc.)
• Inventors: Carullo, Anne, Palmer Quintano, Jennifer, Kassouf, Joyce, Pernodet, Nadine, Collins, Donald, Layman, Dawn, Hafkin, Allan, Fontanet, Osvaldo
• Primary Examiner(s): Coniglio, Audrea B
• Application Number:
  US15/730,904
• Publication Number:
  US 20180064654A1
• Time in Patent Office: 895 Days
• CPC Class Codes: A45D 44/002 Masks for cosmetic treatment of the face
• CPC Class Codes: A45D 44/22 Face shaping devices, e.g. chin straps; Wrinkle removers, e.g. stretching the skin skin stretchers for shaving A45D27/38
• CPC Class Codes: A61K 36/18 Magnoliophyta (angiosperms)
• CPC Class Codes: A61K 36/28 Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
• CPC Class Codes: A61K 8/0212 Face masks
• CPC Class Codes: A61K 8/36 Carboxylic acids; Salts or anhydrides thereof
• CPC Class Codes: A61K 8/64 Proteins; Peptides; Derivatives or degradation products thereof
• CPC Class Codes: A61K 9/70 Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug hollow drug-filled fibres A61K9/0092
• CPC Class Codes: A61K 9/7007 Drug-containing films, membranes or sheets A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence
• CPC Class Codes: A61K 9/7023 Transdermal patches and similar drug-containing composite devices, e.g. cataplasms galenical aspects of iontophoretic devices A61K9/0009; microneedle arrays A61K9/0021; buccal patches A61K9/006
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 2300/25 Peptides having up to 20 amino acids in a defined sequence
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

A sheet pack comprising an absorbent layer impregnated with a treatment composition containing at least one ingredient that when topically applied to skin stimulates a gene that is variably expressed over a 24 hour period in native untreated skin cells; the sheet pack contained in a package with user instructions to topically apply the sheet pack to the skin at a time when the gene that is stimulated by the ingredient is being maximally expressed in native untreated skin cells; and methods for treating skin and methods for making a sheet pack.

Claims

1. A sheet pack in the form of a laminate having a thickness of 0.2 to 1.5 mm comprising a skin penetration enhancing impermeable layer comprised of metallic foil having a thickness ranging from 2 to 15 microns permanently bonded to an absorbent layer comprised of cotton pulp with a heat activated bonding agent which is a thermoplastic material having a melting point ranging from 200 to 300°

C., where the absorbent layer is impregnated with an aqueous based treatment composition having a viscosity of 2 to 1,000 centipoise at 25°

C., containing an ingredient selected from the group consisting of (a) a CLOCK gene activator, (b) a PER gene activator, (c) a BMAL gene activator, (d) a CRY gene activator, or (e) combinations thereof;

wherein the absorbent layer side of the sheet pack laminate is topically applied to the skin for a period of 1 to 60 minutes wherein the skin penetration of the treatment composition is improved compared to a sheet pack containing the same absorbent layer but having no impermeable layer permanently bonded to the absorbent layer.

2. The sheet pack of claim 1 wherein the sheet pack contained in a package with user instructions.

3. The sheet pack of claim 1 wherein the absorbent layer has one or more of the following specifications:

(a) absorbs water from 0.03 to 2.5 ml/gram after 5 seconds per 1 gram measured by the Larose method;

(b) a thickness ranging from 0.1 to 1.0 mm;

(c) a bending resistance of 1.0 to 2.0 mm.m²/gram;

(d) a drape co-efficient ranging from 1 to 70%;

(e) a KES bending rigidity B value of less than or equal to 0.20 gf/cm²/cm; and

(f) a co-efficient of friction of less than 0.45 MIU.

4. The sheet pack of claim 1 wherein the absorbent layer is bonded to the impermeable layer by a bonding agent that is a synthetic polymer having melting point ranging from 221 to 248°

C. and a specific gravity of 915 to 935 kg/m³.

5. The sheet pack of claim 4 wherein the impermeable layer has one or more of the following specifications:

(a) from 98 to 100% aluminum;

(b) a melting point of greater than 650°

C.; and

(c) a specific gravity of 2.5 to 3.0.

6. The sheet pack of claim 1 wherein the impermeable layer causes the treatment composition to show at least a 10% improvement in skin penetration of the treatment composition into the treatment surface when compared to the skin penetration of the treatment composition into the treatment surface with a sheet pack containing the same absorbent layer but with no impermeable layer being bonded to the absorbent layer.

7. The sheet pack of claim 1 wherein the absorbent layer is bonded to the impermeable layer by a bonding agent which is low density polyethylene.

8. The sheet pack of claim 1 wherein the skin treatment composition comprises a PER gene activator and is applied to skin when the PER gene is being maximally expressed in skin cells.

9. The sheet pack of claim 1 wherein the skin treatment composition comprises a BMAL or CRY gene activator and is applied to skin when the BMAL or CRY gene respectively is being maximally expressed in skin cells.

10. The sheet pack of claim 1 where the activator of CLOCK, PER, CRY, or BMAL is one or more of:

Cichoric acid;

Echinacea extract;

Tripeptide-32;

Tetrapeptide-26;

or

an Autophagy activator.

11. The sheet pack of claim 1 wherein the additional skin treatment active is:

(a) a DNA repair enzyme selected from an enzyme that repairs 8-oxo-guanine base damage, an enzyme that repairs T-T-dimers, an enzyme that repairs 6-methyl guanine base damage, T4 endonuclease, Base Excision Repair enzymes, Mismatch Excision Repair enzymes, Nucleotide Excision Repair enzymes, DNA Polymerases, DNA Helicases, and combinations thereof;

(b) a probiotic microorganism selected from Bifidobacteriales, Saccharomyces or Lactobacillales genera;

(c) a proteasome activator selected from algin, alginates, hydrolyzed algin, molasses extract, Trametes extracts, Oleo Europa fruit extract, Acacia Senegal extract, plankton extract, arginine ferulate and combinations thereof;

(d) or combinations thereof.

12. The sheet pack of claim 1 for treating facial or body skin.

13. The sheet pack of claim 2 wherein the user instructions are to apply the sheet pack to the skin at a time ranging from 18:

00 to 24;

00 hours.

14. The sheet pack of claim 2 wherein the user instructions are to apply the sheet pack to the skin at a time ranging from 20:

00 to 24;

00 hours.

15. The sheet pack of claim 2 wherein the user instructions are to apply the sheet pack to the skin at a time ranging from 18:

00 to 24;

00 hours for 1 to 60 minutes.

16. A method for making a sheet pack comprising the steps of:

(i) identifying a gene selected from the group consisting of (a) a CLOCK gene, (b) a PER gene, (c) a BMAL gene, (d) a CRY gene, or (e) combinations thereof that is variably expressed over a 24 hour period in skin cells;

(ii) forming the sheet pack in the form of a laminate having a thickness of 0.2 to 1.5 mm comprised of skin penetration enhancing impermeable metallic foil layer having a thickness ranging from 2 to 15 microns permanently bonded to a fabric absorbent layer comprising cotton pulp with a heat activated bonding agent which is a thermoplastic material having a melting point ranging from 200 to 300°

C.; and

(iii) impregnating the absorbent layer with an aqueous based skin treatment composition having a viscosity of 2 to 1,000 centipoise at 25°

C. containing an ingredient selected from the group consisting of (a) a CLOCK gene activator, (b) a PER gene activator, (c) a BMAL gene activator, (d) CRY gene activator, or (e) combinations thereof wherein the skin penetration of the treatment composition is improved compared to a sheet pack containing the same absorbent layer but having no impermeable layer permanently bonded to the absorbent layer when topically applied to skin for a period of 1 to 60 minutes.

17. The method of claim 16 wherein the gene that is variably expressed over a 24 hour period is maximally expressed at times ranging from 18:

00 to 24;

00 hours and is one or more of PER, CLOCK, BMAL, or CRY.