Sustained release delivery of active agents to treat glaucoma and ocular hypertension
First Claim
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1. A method of using an implant for insertion into a lacrimal canaliculus, comprising:
- placing the implant into the lacrimal canaliculus, wherein the implant comprises;
a first member defining a first axis and having a first end along the first axis, wherein the first member is configured to extend into the canaliculus;
a second member defining a second axis and having a second end along the second axis, wherein the second member is configured to reside in a vertical portion of the canaliculus and to extend to an opening of, or out of the opening of, an associate lacrimal punctum;
a third member connecting the first end of the first member and the second end of the second member at a first angle to form an angled intersection;
the third member comprises a bore defining a third axis and a second angle and having an upper surface;
wherein the bore is configured to be accessible to an insertion tool for facilitating insertion of the implant and extends from the upper surface into the third member; and
further wherein the first angle is defined by the first axis with respect to the second axis and the second angle is defined by the first axis with respect to the third axis;
wherein the first angle is from 30 degrees to 150 degrees;
wherein the second angle is from 15 degrees to 90 degrees.
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Abstract
A method of decreasing intraocular pressure (IOP) in an eye of a patient in need thereof includes implanting a first lacrimal implant through a firsts punctum and into a first lacrimal canaliculus of the eye of the patient. The method may further comprise implanting a second lacrimal implant through a second punctum and into a second lacrimal canaliculus of the eye of the patient, and releasing, on a sustained basis a therapeutically effective amount of an intraocular pressure-reducing therapeutic agent.
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Citations
30 Claims
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1. A method of using an implant for insertion into a lacrimal canaliculus, comprising:
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placing the implant into the lacrimal canaliculus, wherein the implant comprises; a first member defining a first axis and having a first end along the first axis, wherein the first member is configured to extend into the canaliculus; a second member defining a second axis and having a second end along the second axis, wherein the second member is configured to reside in a vertical portion of the canaliculus and to extend to an opening of, or out of the opening of, an associate lacrimal punctum; a third member connecting the first end of the first member and the second end of the second member at a first angle to form an angled intersection;
the third member comprises a bore defining a third axis and a second angle and having an upper surface;wherein the bore is configured to be accessible to an insertion tool for facilitating insertion of the implant and extends from the upper surface into the third member; and
further wherein the first angle is defined by the first axis with respect to the second axis and the second angle is defined by the first axis with respect to the third axis;wherein the first angle is from 30 degrees to 150 degrees; wherein the second angle is from 15 degrees to 90 degrees. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method of using an implant for insertion into a lacrimal canaliculus, comprising:
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placing the implant into the lacrimal canaliculus, wherein the implant comprises; a first member defining a first axis and having a first end along the first axis, wherein the first member is configured to extend into the canaliculus; a second member defining a second axis and having a second end along the second axis, wherein the second member is configured to reside in a vertical portion of the canaliculus and to extend to an opening of, or out of the opening of, an associate lacrimal punctum; a cavity that is configured to house a therapeutic agent core, wherein the cavity extends into the second member along the second axis; a third member connecting the first end of the first member and the second end of the second member at a first angle to form an angled intersection;
the third member comprises a bore defining a third axis and a second angle and having an upper surface;wherein the bore is configured to be accessible to an insertion tool for facilitating insertion of the implant and extends from the upper surface into the third member; and
further wherein the first angle is defined by the first axis with respect to the second axis and the second angle is defined by the first axis with respect to the third axis;wherein the first angle is from 30 degrees to 150 degrees; wherein the second angle is from 15 degrees to 90 degrees. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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Specification