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Silylated biomolecule-based hydrogel for culturing cardiomyocytes and stem cells, and use of the hydrogel thereof for treating heart failure

  • US 10,632,203 B2
  • Filed: 04/10/2018
  • Issued: 04/28/2020
  • Est. Priority Date: 06/03/2011
  • Status: Active Grant
First Claim
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1. A method of treating heart failure including administration by injection into myocardium of an aqueous composition which has a physiological pH, said composition comprising:

  • i) cardiomyocytes or stem cells which are able to differentiate into cardiomyocytes; and

    ii) a hydrogel solution comprising from 0.8 to 1.5% w/v of silylated-hydroxypropylmethylcellulose (Si-HPMC) capable of forming a pH dependent self-reticulating hydrogel.

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