Obstructive sleep apnea treatment devices, systems and methods
First Claim
1. A hypoglossal stimulation system for delivery of a stimulation signal to a hypoglossal nerve of a patient to treat obstructive sleep apnea, the stimulation system comprising:
- an implantable pulse generator having a stimulation port and a respiratory sensing port;
a respiratory sensing lead having a respiratory sensing lead connector coupled to a sensor, the respiratory sensing lead connector being configured to engage the respiratory sensing port; and
a stimulation lead having a lead body with a first lead body end supporting a stimulation lead connector configured to engage the stimulation port and an opposing second lead body end supporting a cuff, the first lead body end having a first sigmoid portion and the second lead body end having a second sigmoid portion, the stimulation lead further having an anchor disposed on the lead body between the first and second sigmoid portions.
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Accused Products
Abstract
A method including chronically implanting a nerve cuff electrode on a portion of a hypoglossal nerve, chronically implanting a respiration sensing lead subcutaneously in a thorax of a patient, the respiration sensing lead having a plurality of bio-impedance electrodes defining at least one bio-impedance vector. The method may also include sensing a bio-impedance signal corresponding to respiration via a bio-impedance vector on an anterior side of the thorax, analyzing the bio-impedance signal to identify onsets of expiration, predicting an onset of a future expiratory phase, and delivering a stimulus to the portion of the hypoglossal nerve via the nerve cuff electrode, wherein the stimulus is delivered as a function of the bio-impedance signal; wherein stimulus delivery is initiated before the onset of the future expiratory phase and continued during an entire inspiratory phase, and wherein the method is performed without identifying an onset of an inspiratory phase.
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Citations
21 Claims
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1. A hypoglossal stimulation system for delivery of a stimulation signal to a hypoglossal nerve of a patient to treat obstructive sleep apnea, the stimulation system comprising:
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an implantable pulse generator having a stimulation port and a respiratory sensing port; a respiratory sensing lead having a respiratory sensing lead connector coupled to a sensor, the respiratory sensing lead connector being configured to engage the respiratory sensing port; and a stimulation lead having a lead body with a first lead body end supporting a stimulation lead connector configured to engage the stimulation port and an opposing second lead body end supporting a cuff, the first lead body end having a first sigmoid portion and the second lead body end having a second sigmoid portion, the stimulation lead further having an anchor disposed on the lead body between the first and second sigmoid portions. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A stimulation lead for use with a neurostimulation device to deliver a stimulation signal to a hypoglossal nerve of a patient, the stimulation lead comprising:
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a cuff configured to be disposed about the nerve of the patient; a connector configured to engage the neurostimulation device; a lead body extending between the connector and the cuff, the lead body having a first section and a second section, the first section engaging the connector and having a first sigmoid portion, the second section engaging the cuff and having a second sigmoid portion; and an anchor disposed on the lead body between the first sigmoid portion and the second sigmoid portion. - View Dependent Claims (9, 10, 11, 12, 13, 14)
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15. A stimulation lead for use with a neurostimulation device to deliver a stimulation signal to a hypoglossal nerve of a patient, the stimulation lead comprising:
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a cuff configured to be disposed about the nerve of the patient; a connector configured to engage the neurostimulation device; a lead body extending between the connector and the cuff, the lead body having a first portion engaging the connector and a second portion engaging the cuff, the first portion having a first variable-length section and the second portion having a second variable-length section, the first and second variable-length sections each having a relaxed length and a deformed length that is longer than the relaxed length; and an anchor disposed on the lead body between the first and second variable-length sections. - View Dependent Claims (16, 17, 18, 19, 20, 21)
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Specification