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Compositions, systems, and methods for detecting the presence of polymer subunits using chemiluminescence

  • US 10,633,694 B2
  • Filed: 09/10/2015
  • Issued: 04/28/2020
  • Est. Priority Date: 09/12/2014
  • Status: Active Grant
First Claim
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1. A composition including:

  • a substrate;

    a first polynucleotide coupled to the substrate;

    a second polynucleotide hybridized to the first polynucleotide;

    a catalyst coupled to a first nucleotide at the 3′

    end of the second polynucleotide, wherein the catalyst is operable to cause a chemiluminogenic molecule to emit a photon, wherein the first nucleotide is coupled to a first moiety, and the catalyst is coupled to a second moiety, wherein the first nucleotide and the catalyst are coupled via the first and second moieties; and

    a polymerase capable of extending the second polynucleotide hybridized to the first polynucleotide.

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