Antimicrobial compositions

• US 10,638,755 B2
• Filed: 03/06/2014
• Issued: 05/05/2020
• Est. Priority Date: 03/08/2013
• Status: Active Grant

• Current Assignee: Symrise AG
• Original Assignee: Symrise AG
• Inventors: Pesaro, Manuel, Holscher, Bernd, Schmaus, Gerhard, Kohler, Antje
• Primary Examiner(s): Qazi, Sabiha N
• Application Number:
  US14/773,071
• Publication Number:
  US 20160015031A1
• Time in Patent Office: 2,252 Days
• Field of Search: 424 65, 424 66
• CPC Class Codes: A01N 31/02 Acyclic compounds
• CPC Class Codes: A01N 31/04 Oxygen or sulfur attached to an aliphatic side-chain of a carbocyclic ring system
• CPC Class Codes: A01N 31/14 Ethers
• CPC Class Codes: A01N 35/04 containing aldehyde or keto groups, or thio analogues thereof, directly attached to an aromatic ring system, e.g. acetophenone; Derivatives thereof, e.g. acetals
• CPC Class Codes: A23L 3/34635 Antibiotics
• CPC Class Codes: A23L 33/127 Antibiotics
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A61K 8/34 Alcohols
• CPC Class Codes: A61K 8/345 containing more than one hydroxy group
• CPC Class Codes: A61K 8/35 Ketones, e.g. benzophenone
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61Q 15/00 Anti-perspirants or body deodorants deodorisation of air A61L9/00
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations
• CPC Class Codes: C11D 3/48 Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions

Abstract

Suggested is a antimicrobial agent An antimicrobial composition comprising (a) at least one acetophenone derivative of formula (I) in which R₁ stands for hydrogen or methyl, and R₂ stands for hydrogen, hydroxyl or a —OCH₃ group, or a cosmetically or pharmaceutically acceptable salt thereof, and (b) at least one second antimicrobial agent.

Claims

1. An antimicrobial composition consisting of

(a) 4-hydroxyacetophenone

and

(b) one second antimicrobial agent selected from the group consisting of 2-phenylethyl alcohol, 3-phenyl propanol, benzyl alcohol, 1,3 propandiol, 3-heptoyl-2,2-propandiol, 1, 2-pentanediol, 1,2-hexandiol, 1,2 octandiol, 2-phenoxyethanol, 3-hexoxy-propan-1,2-diol, 3-heptoxy-propan-1,2-diol, 3-octoxy-propan-1,2-diol, ethylhexyl glycerin, 3-benzyloxy-propan-1,2-diol, wherein component (b) is present in an amount of from 1 to about 25 weight percent based upon the total weight of the antimicrobial composition.

2. The composition of claim 1 wherein the second antimicrobial agent is present in an amount of from 2 to 20 weight percent based on the total weight of the composition.

3. The composition of claim 1 wherein the second antimicrobial agent is present in an amount of from 5 to 10 weight percent based on the total weight of the composition.

4. The composition of claim 3 wherein the second antimicrobial agent is selected from the group consisting of 2-phenylethyl alcohol, 3-phenyl propanol, benzyl alcohol, 1,2-pentanediol, 1,2-hexandiol, 1,2-octanediol, 2-phenoxyethanol, and ethylhexyl glycerin.

5. An antimicrobial composition consisting of

(a) 4-hydroxyacetophenone, and

(b) one second antimicrobial agent selected from the group consisting of 2-phenylethyl alcohol, 3-phenyl propanol, benzyl alcohol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 2-phenoxyethanol and ethylhexyl glycerin wherein component (b) is present in an amount of from 1 to about 25 weight percent based upon the total weight of the antimicrobial composition.