Measurement probe, measurement device, and attachment mechanism

• US 10,638,928 B2
• Filed: 05/18/2015
• Issued: 05/05/2020
• Est. Priority Date: 05/29/2014
• Status: Active Grant

• Current Assignee: Sharp Life Science Corporation
• Original Assignee: Sharp Life Science Corporation
• Inventors: Yamanaka, Mikihiro
• Primary Examiner(s): Winakur, Eric F
• Assistant Examiner(s): Liu, Chu Chuan
• Application Number:
  US15/314,208
• Publication Number:
  US 20170188827A1
• Time in Patent Office: 1,814 Days
• CPC Class Codes: A61B 10/02 Instruments for taking cell samples or for biopsy A61B10/0038 and A61B10/0045 take precedence; needle locating or guiding means A61B17/3403; samplers for enzymology or microbiology C12M1/26; sampling or preparing biological specimens G01N33/48
• CPC Class Codes: A61B 2560/0462 Apparatus with built-in sensors
• CPC Class Codes: A61B 2562/0233 Special features of optical sensors or probes classified in A61B5/00
• CPC Class Codes: A61B 2562/146 for optical coupling
• CPC Class Codes: A61B 5/00 Measuring for diagnostic purposes radiation diagnosis A61B6/00; diagnosis by ultrasonic, sonic or infrasonic waves A61B8/00; Identification of persons
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14556 by fluorescence A61B5/14555 takes precedence
• CPC Class Codes: A61B 5/6826 Finger

Abstract

Provided is a measurement probe of which hygiene can be easily secured. The measurement probe (1) receives fluorescence emitted by radiation of excitation light to a fingertip (90). The measurement probe (1) includes: a radiating portion that radiates the excitation light; a light-receiving portion that receives the fluorescence; a sleeve (16) disposed at a front end portion of the radiating portion or the light-receiving portion; and a transparent quartz plate (15) disposed at a front end surface (14I) of the radiating portion or the light-receiving portion. The sleeve (16) is provided with an opening in which the quartz plate (15) is detachably mounted.

Claims

1. A measurement probe that receives fluorescence emitted by radiation of excitation light to a biological sample, the measurement probe comprising:

a radiating portion that radiates the excitation light;

a light receiving portion that receives the fluorescence;

a support member disposed at a front end portion of the radiating portion or the light-receiving portion; and

a transparent protective member disposed at a front end surface of the radiating portion or the light-receiving portion,

wherein the support member is provided with an opening in which the transparent protective member is detachably mounted,

the support member includes

a first support member that is disposed on the front end portion, and

a second support member that is disposed to be movable with respect to the first support member and fixes a relative positional relationship between the transparent protective member and the first support member, and

inclined surfaces are formed on an outer edge portion of the transparent protective member and on an inner edge portion of the second support member, respectively, and an angle between the inclined surfaces is defined such that the transparent protective member and the second support member come into contact with each other on the inclined surfaces.

2. The measurement probe according to claim 1,

wherein in a case where a filler, which is capable of filing a gap formed between a surface of the transparent protective member and a surface of the biological sample, fills the gap,

the transparent protective member has a refractive index higher than air, and

the refractive index of the filler is more approximate to a refractive index of the transparent protective member than to the refractive index of the air.

3. The measurement probe according to claim 1,

wherein the transparent protective member is a quartz plate.

4. A measurement device comprising:

the measurement probe according to claim 1;

a light source that emits the excitation light; and

a detector that detects a fluorescence intensity of a wavelength of the fluorescence.

5. An attachment mechanism which is provided to a measurement probe that receives fluorescence emitted by radiation of excitation light to be a biological sample, the measurement probe comprising:

a radiating portion that radiates the excitation light; and

a light receiving portion that receives the fluorescence,

the attachment mechanism comprising;

a transparent protective member; and

a support member,

wherein the attachment mechanism is detachably mounted at a front end portion of the radiating portion or the light-receiving portion,

the support member is disposed at the front end portion as a result of the attachment mechanism being mounted at the front end portion,

the transparent protective member is disposed at a front end surface of the radiating portion or the light-receiving portion as a result of the attachment mechanism being mounted at the front end portion,

the support member is provided with an opening in which the protective member is detachably mounted,

the support member includes

a first support member that is disposed on the front end portion, and

a second support member that is disposed to be movable with respect to the first support member and fixes a relative positional relationship between the transparent protective member and the first support member, and

inclined surfaces are formed on an outer edge portion of the transparent protective member and on an inner edge portion of the second support member, respectively, and an angle between the inclined surfaces is defined such that the transparent protective member and the second support member come into contact with each other on the inclined surfaces.