Systems and methods for diagnosing coronary microvascular disease

• US 10,638,939 B2
• Filed: 03/11/2014
• Issued: 05/05/2020
• Est. Priority Date: 03/12/2013
• Status: Active Grant

• Current Assignee: Volcano Corporation (Koninklijke Philips N.V.)
• Original Assignee: Philips Image Guided Therapy Corporation (Koninklijke Philips N.V.)
• Inventors: Collins, Donna, Gaddis, Mary Lynn, Kemp, Nathaniel J., Sturm, Bernhard
• Primary Examiner(s): Luong, Peter
• Application Number:
  US14/204,277
• Publication Number:
  US 20140276036A1
• Time in Patent Office: 2,247 Days
• CPC Class Codes: A61B 2090/3966 Radiopaque markers visible in an X-ray image
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61B 5/0275 using tracers, e.g. dye dilution
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: A61B 5/743 Displaying an image simultaneously with additional graphical information, e.g. symbols, charts, function plots
• CPC Class Codes: A61B 5/746 Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms alarms per se G08B
• CPC Class Codes: A61B 8/0883 for diagnosis of the heart
• CPC Class Codes: A61B 8/0891 for diagnosis of blood vessels
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61B 8/488 involving Doppler signals
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers

Abstract

The invention provides systems and methods for assessing the vasculature of a subject. In certain aspects, systems and methods of the invention involve receiving functional flow data of a subject via a data collector co-located with a radiopaque label, receiving imaging data of the vasculature including the radiopaque label, generating a vasculature map corresponding to the functional flow data, and displaying the vasculature map image on a monitor.

Claims

1. A system for assessing vasculature of a subject, the system comprising:

one or more processors in communication with an intraluminal device comprising a sensor configured to obtain functional flow data while positioned within the vasculature, wherein the one or more processors are configured to;

receive the functional flow data from the sensor;

receive an external image of the vasculature;

determine a functional flow parameter at a plurality of locations along the vasculature based on the functional flow data;

determine an alert when the functional flow parameter exceeds a threshold level at a location of the plurality of locations along the vasculature, the threshold level associated with a disease state of the vasculature;

output, to a monitor in communication with the one or more processors, the external image comprising;

the vasculature comprising different colors based on the functional flow parameter at the plurality of locations, the different colors corresponding to different threshold levels of the functional flow parameter; and

an indicator corresponding to the alert and displayed on or adjacent to the location along the vasculature identified by the alert such that the indicator visually links the location to the functional flow parameter at the location.

2. The system of claim 1, further comprising:

the intraluminal device, wherein the intraluminal device further comprises a radiopaque label co-located with the sensor, wherein imaging data associated with the external image includes the radiopaque label.

3. The system of claim 1, wherein the one or more processors are further configured to:

co-register the functional flow data with the external image of the vasculature.

4. The system of claim 1, wherein the vasculature in the external image further comprises a location of the sensor.

5. The system of claim 4, wherein the location of the sensor is a real-time location of the sensor.

6. The system of claim 1, the one or more processors are further configured to:

output, to the monitor, a functional flow image representative of at least one of the functional flow data or the functional flow parameter.

7. The system of claim 6, wherein the functional flow image comprises at least one of a numerical value, a waveform, or a graph.

8. The system of claim 6, wherein the one or more processors are further configured to output, to the monitor, a composite image comprising the external image of the vasculature and the functional flow image.

9. The system of claim 1, wherein the indicator corresponding to the alert comprises at least one of the functional flow data or the functional flow parameter at the location along the vasculature identified by the alert.

10. The system of claim 9, wherein the indicator comprises at least one of a numerical value, a waveform, or a graph associated with at least one of the functional flow data or the functional flow parameter at the location along the vasculature identified by the alert.

11. The system of claim 1, wherein the indicator comprises at least one of a shape, a color-coded indicator, a pulsating indicator, or a callout marker.

12. The system of claim 1,

wherein the sensor comprises a pressure sensor,

wherein the functional flow data comprises pressure data, and

wherein the functional flow parameter comprises a pressure ratio.

13. The system of claim 12, wherein the pressure ratio comprises fractional flow reserve (FFR).

14. The system of claim 1,

wherein the sensor comprises a flow sensor,

wherein the functional flow data comprises flow data, and

wherein the functional flow parameter comprises a flow ratio.

15. The system of claim 14, wherein the flow ratio comprises coronary flow reserve (CFR).

16. The system of claim 1, wherein the external image of the vasculature comprises at least one of an angiogram, a computed tomography (CT) scan, or a magnetic resonance imaging (MRI) scan.