Subject information acquisition apparatus

• US 10,639,011 B2
• Filed: 04/18/2017
• Issued: 05/05/2020
• Est. Priority Date: 04/08/2011
• Status: Active Grant

• Current Assignee: Canon Kabushiki Kaisha (Canon Inc.)
• Original Assignee: Canon Kabushiki Kaisha (Canon Inc.)
• Inventors: Oikawa, Katsuya, Nagae, Kenichi, Yamakawa, Makoto, Shiina, Tsuyoshi
• Primary Examiner(s): Cattungal, Sanjay
• Application Number:
  US15/490,776
• Publication Number:
  US 20170215847A1
• Time in Patent Office: 1,113 Days
• Field of Search: 600437-469
• CPC Class Codes: A61B 8/085 for locating body or organic structures, e.g. tumours, calculi, blood vessels, nodules
• CPC Class Codes: A61B 8/0858 involving measuring tissue layers, e.g. skin, interfaces
• CPC Class Codes: A61B 8/4483 characterised by features of the ultrasound transducer
• CPC Class Codes: A61B 8/485 involving measuring strain or elastic properties
• CPC Class Codes: A61B 8/5223 for extracting a diagnostic or physiological parameter from medical diagnostic data for algorithms to analyse biomedical images G06T7/0012
• CPC Class Codes: A61B 8/585 Automatic set-up of the device
• CPC Class Codes: G01S 7/52042 determining elastic properties of the propagation medium or of the reflective target diagnostic techniques involving the measurement of strain A61B8/485
• CPC Class Codes: G16H 50/30 for calculating health indices; for individual health risk assessment

Abstract

Viscoelastic characteristics in a subject are imaged by a simple method. A viscoelasticity measurement reference layer whose elastic modulus and viscosity coefficient are known is included between an ultrasonic wave transmitting/receiving probe and the subject and distributions of elastic modulus and viscosity coefficient inside the subject are calculated from a change over time of strain generated in the viscoelasticity measurement reference layer and the subject according to a pressure applied to the subject which changes over time and known elastic modulus and viscosity coefficient of the viscoelasticity measurement reference layer.

Claims

1. A subject information acquisition apparatus for transmitting, through a reference layer, an elastic wave to a subject, receiving, through the reference layer, the elastic wave reflected from inside the subject, and acquiring information inside the subject, the subject information acquisition apparatus comprising:

a conversion device configured to receive the elastic wave and convert the elastic wave into an electrical signal; and

a memory and processor which function as each unit comprising;

a measuring unit configured to measure strain of the subject and strain of the reference layer which are generated when a pressure is applied to the subject and the reference layer interposed between the conversion device and the subject by using the electrical signal; and

a calculation unit configured to calculate a viscosity coefficient (TO) of the subject by using a viscosity coefficient and an elastic modulus of the reference layer, the strain of the subject, and the strain of the reference layer,

wherein

the pressure applied to the subject and the reference layer is periodic pressure application including releasing the pressure, and

the calculation unit calculates the viscosity coefficient (η

) of the subject by using an area of a hysteresis loop drawn with strain values of the subject and strain values of the reference layer which are generated by the periodic pressure.

2. The subject information acquisition apparatus according to claim 1, wherein in a case the periodic pressure application is repeatedly performed, the calculation unit calculates an area of the hysteresis loop for each period, and averages the calculated areas.

3. The subject information acquisition apparatus according to claim 2, wherein

the pressure applied to the subject and the reference layer is instantaneously increased to a certain pressure and thereafter the certain pressure is held for a certain time period, and

the calculation unit calculates the viscosity coefficient (η

) of the subject by using a strain value of the subject and a strain value of the reference layer after the pressure applied to the subject and the reference layer is instantaneously increased to a certain pressure.

4. The subject information acquisition apparatus according to claim 1, further comprising a control unit configured to display on a display unit a cross-sectional image of inside of the subject based on the electric signals and an image related to viscosity of the subject.

5. The subject information acquisition apparatus according to claim 4, wherein the control unit displays on the display unit, the cross-sectional image and the image related to viscosity of the subject in parallel, switching, or an overlaid manner.

6. A subject information acquisition apparatus for transmitting, through a reference layer, an elastic wave to a subject, receiving, through the reference layer, the elastic wave reflected from inside the subject, and acquiring information inside the subject, the subject information acquisition apparatus comprising:

a conversion device configured to receive the elastic wave and convert the elastic wave into an electrical signal; and

a memory and processor which function as each unit comprising;

a measuring unit configured to measure strain of the subject and strain of the reference layer which are generated when a pressure is applied to the subject and the reference layer interposed between the conversion device and the subject by using the electrical signal, the reference layer having a viscosity coefficient and an elastic modulus; and

a calculation unit configured to calculate a viscosity coefficient (TO) of the subject by using the viscosity coefficient and the elastic modulus of the reference layer, the strain of the subject, and the strain of the reference layer,

wherein

the calculation unit calculates the viscosity coefficient (η

) of the subject by using a delay time between the change over time of the strain value of the subject and the change over time of the strain value of the reference layer which are generated by the application of the pressure.

7. The subject information acquisition apparatus according to claim 6, further comprising a control unit configured to display on a display unit a cross-sectional image of inside of the subject based on the electric signals and an image related to viscosity of the subject.

8. The subject information acquisition apparatus according to claim 7, wherein the control unit displays on the display unit, the cross-sectional image and the image related to viscosity of the subject in parallel, switching, or an overlaid manner.

9. A subject information acquisition apparatus for transmitting, through a reference layer, an elastic wave to a subject, receiving, through the reference layer, the elastic wave reflected from inside the subject, and acquiring information inside the subject, the subject information acquisition apparatus comprising:

a conversion device configured to receive the elastic wave and convert the elastic wave into an electrical signal; and

a memory and processor which function as each unit comprising;

a measuring unit configured to measure strain of the subject and strain of the reference layer which are generated when a pressure is applied to the subject and the reference layer interposed between the conversion device and the subject by using the electrical signal; and

a calculation unit configured to calculate a stress applied to the subject by using a viscosity coefficient of the reference layer, a Young'"'"'s modulus of the reference layer, and the strain of the reference layer, according to the following equation;

10. The subject information acquisition apparatus according to claim 9, wherein the calculation unit is further configured to calculate a viscosity coefficient (η

) of the subject by using the calculated stress and using an area of a hysteresis loop drawn with strain values of the subject.

11. The subject information acquisition apparatus according to claim 9, further comprising an imaging unit that generates a viscoelasticity cross-sectional image of the subject.

12. The subject information acquisition apparatus according to claim 11, wherein the imaging unit causes a display unit to display the viscoelasticity cross-sectional image, the elastic modulus and the viscosity coefficient being respectively assigned to any one of hue, chroma, and brightness.

13. A subject information acquisition method for acquiring information on inside of a subject by using echo signals from the subject, the method comprising:

transmitting, through a reference layer, an elastic wave to the subject;

receiving, through the reference layer, the elastic wave reflected in the subject;

measuring strain of the subject and strain of the reference layer which are generated when a pressure is applied to the subject and the reference layer; and

calculating a viscosity coefficient (η

) of the subject by using a viscosity coefficient and an elastic modulus of the reference layer, the strain of the subject, and the strain of the reference layer,

wherein

the pressure applied to the subject and the reference layer is periodic pressure application including releasing the pressure, and

calculating the viscosity coefficient (η

) of the subject is performed by using an area of a hysteresis loop drawn with strain values of the subject and strain values of the reference layer which are generated by the periodic pressure.

14. The method according to claim 13, wherein in a case the periodic pressure application is repeatedly performed,

calculating the viscosity coefficient includes calculating an area of the hysteresis loop for each period and averaging the calculated areas.

15. The method according to claim 14, wherein in a case the pressure applied to the subject and the reference layer is instantaneously increased to a certain pressure and thereafter the certain pressure is held for a certain time period,

the viscosity coefficient (η

) of the subject is calculated by using a strain value of the subject and a strain value of the reference layer after the pressure applied to the subject and the reference layer is instantaneously increased to a certain pressure.

16. The method according to claim 13, further comprising:

displaying on a display unit a cross-sectional image of inside of the subject based on obtained by the receiving and an image related to viscosity of the subject.

17. The method according to claim 16, wherein the displaying includes displaying the cross-sectional image and the image related to viscosity of the subject in parallel, switching, or an overlaid manner.

18. A subject information acquisition method for acquiring information on inside of a subject by using echo signals from the subject, the method comprising:

transmitting, through a reference layer, an elastic wave to the subject;

receiving, through the reference layer, the elastic wave reflected in the subject;

measuring strain of the subject and strain of the reference layer which are generated when a pressure is applied to the subject and the reference layer; and

calculating a viscosity coefficient (η

) of the subject by using a viscosity coefficient and an elastic modulus of the reference layer, the strain of the subject, and the strain of the reference layer,

wherein

calculating the viscosity coefficient (η

) of the subject is performed by using a delay time between the change over time of the strain value of the subject and the change over time of the strain value of the reference layer which are generated by the application of the pressure.

19. The method according to claim 18, further comprising:

displaying on a display unit a cross-sectional image of inside of the subject based on signals obtained by the receiving and an image related to viscosity of the subject.

20. The method according to claim 19, wherein the displaying includes displaying the cross-sectional image and the image related to viscosity of the subject in parallel, switching, or an overlaid manner.

21. A subject information acquisition method for acquiring information on inside of a subject by using echo signals from the subject, the method comprising:

transmitting, through a reference layer, an elastic wave to the subject;

receiving, through the reference layer, the elastic wave reflected in the subject;

measuring strain of the subject and strain of the reference layer which are generated when a pressure is applied to the subject and the reference layer; and

calculating a stress applied to the subject by using a viscosity coefficient of the reference layer, a Young'"'"'s modulus of the reference layer, and the strain of the reference layer, according to the following equation;

22. The method according to claim 21, further comprising calculating a viscosity coefficient (TO) of the subject by using the calculated stress and using an area of a hysteresis loop drawn with strain values of the subject.

23. The method according to claim 21, further comprising generating a viscoelasticity cross-sectional image of the subject.

24. The method according to claim 23, further comprising displaying the viscoelasticity cross-sectional image, the elastic modulus and the viscosity coefficient being respectively assigned to any one of hue, chroma, and brightness.