Method for detecting circulating cells in superficial body fluids
First Claim
1. An in vitro method for detecting and quantifying circulating cells in superficial body fluids of a subject comprisinga) placing an ultrasound-based device in contact with a liquid sample isolated from a superficial body fluid of the subject for obtaining a ultrasound data of said liquid sample;
- b) analyzing the ultrasound data obtained in step a) by a data processing system which provides information about cells and their concentration in the fluid, andc) correlating the information obtained in step b) with the presence and amount of circulating cells in the individual,wherein the ultrasound-based device operates at a central frequency in the range of 10-100 MHz and at a pulse duration between 25-1,000 ns, and at a wavelengths between 15 and 150 μ
m.
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Abstract
The present invention relates to a method for measuring circulating cells in superficial body fluids by means of high-frequency-based device. The method can be used for detecting circulating cells in the fluids of an individual without the necessity of extracting a sample of the individual, being useful as a diagnostic tool and for monitoring the effectiveness of a treatment administered to an individual suffering from a viral, protozoal, fungal and/or bacterial disease.
17 Citations
20 Claims
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1. An in vitro method for detecting and quantifying circulating cells in superficial body fluids of a subject comprising
a) placing an ultrasound-based device in contact with a liquid sample isolated from a superficial body fluid of the subject for obtaining a ultrasound data of said liquid sample; -
b) analyzing the ultrasound data obtained in step a) by a data processing system which provides information about cells and their concentration in the fluid, and c) correlating the information obtained in step b) with the presence and amount of circulating cells in the individual, wherein the ultrasound-based device operates at a central frequency in the range of 10-100 MHz and at a pulse duration between 25-1,000 ns, and at a wavelengths between 15 and 150 μ
m. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A non-invasive method for detecting and quantifying circulating cells in superficial body fluids comprising
a) placing an ultrasound-based device on the skin of the subject for obtaining a ultrasound data of the a superficial body fluid under the skin; -
b) analyzing the ultrasound data obtained in step a) by a data processing system which provides information about cells and their concentration in the fluid, and c) correlating the information obtained in step b) with the presence and amount of circulating cells in the subject, wherein the ultrasound-based device operates at a central frequency in the range of 10-50 MHz, and at a pulse duration between 50-1,000 ns, and at a wavelength between 30 and 150 μ
m. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification