Oncological ameliorization by irradiation and/or ensonification of tumor vascularization

• US 10,639,096 B2
• Filed: 06/28/2010
• Issued: 05/05/2020
• Est. Priority Date: 06/27/2009
• Status: Active Grant

• Current Assignee: Alexander Shelman-Cohen, Nathan Cohen
• Original Assignee: Alexander Shelman-Cohen, Nathan Cohen
• Inventors: Cohen, Nathan, Shelman-Cohen, Alexander
• Primary Examiner(s): Della, Jaymi E
• Application Number:
  US12/825,297
• Publication Number:
  US 20110130689A1
• Time in Patent Office: 3,599 Days
• Field of Search: 606 27- 52, 607 96-131, 607154-156
• CPC Class Codes: A61B 18/1477 Needle-like probes
• CPC Class Codes: A61B 18/18 by applying electromagnetic radiation, e.g. microwaves radiation therapy A61N5/00
• CPC Class Codes: A61B 2018/00083 low, i.e. electrically insulating
• CPC Class Codes: A61B 2018/00196 reciprocating lengthwise
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 2018/1425 Needle
• CPC Class Codes: A61B 2218/002 Irrigation
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00

Abstract

Techniques are disclosed, including methods and systems/apparatus, that can be used to treat cancerous tissue by exploiting the fact that such tissues have vascular branching with fractal descriptions and fractal dimensions, which are different from those found in normal soft tissue vascular branching. Such fractal branching of diseased tissue can produce resonances, or preferential energy absorption, when irradiated by either ultrasound and/or radio frequencies of EM energy; these resonances are not shared by the vascularization in normal soft tissue. Accordingly, one or more specific arrangements of multiband radiation (e.g., RF and/or ultrasonic) used to irradiate such diseased tissue will cause heating and possibly localized necropsy of tumor blood vessels, with little or minimal damage to surrounding healthy tissue. Embodiments can utilize ablation devices in conjunction with RF and/or ultrasonic sources. Embodiments can further utilize chemotherapy (before, during, or after hyperthermic treatment) for enhancing cancer treatment.

Claims

1. A multi-band RF transmitter system for ameliorization and reduction of diseased tissue, the multi-band RF transmitter system comprising:

an energy source configured and arranged to produce radiofrequency (RF) energy, wherein the RF energy includes non-harmonic, non-continuous multiband spectral radiation adapted to a fractal-shaped vascularization of the diseased tissue; and

a transmitter configured to receive the RF energy produced by the energy source and direct it to a location including the diseased tissue for effecting heating of the diseased tissue,

wherein the transmitter includes a RF antenna, and

wherein at least a portion of the transmitter has a fractal shape, wherein the fractal shape is a second-order deterministic fractal, wherein the transmitter is operative to transmit the multiband radiation, and

wherein the non-continuous multiband spectral radiation is adapted to match one or more resonance frequencies of the fractal-shaped vascularization of the diseased tissue, wherein the transmitter is configured to supply the RF energy matched to the one or more resonance frequencies of the diseased tissue at the location; and

wherein the RF antenna further comprises an aperture engine surface having a first layer of antenna arrays and a second layer of a metal-fractal backplane layer, wherein the first layer of antenna arrays includes an array of aperture antennas.

2. The system of claim 1, wherein the energy source is configured to produce the RF energy within a range of 1-100 MHz.

3. The system of claim 1, further comprising a chemotherapeutic agent.