High modulus polymeric ejector mechanism, ejector device, and methods of use

• US 10,639,194 B2
• Filed: 09/06/2017
• Issued: 05/05/2020
• Est. Priority Date: 12/12/2011
• Status: Active Grant

• Current Assignee: Eyenovia Inc.
• Original Assignee: Eyenovia Inc.
• Inventors: Hunter, Charles Eric, Germinario, Louis Thomas, Wilkerson, Jonathan Ryan, Lynch, Iyam, Brown, Joshua Richard
• Primary Examiner(s): Mensh, Andrew J
• Application Number:
  US15/697,099
• Publication Number:
  US 20180116871A1
• Time in Patent Office: 972 Days
• Field of Search: 604295, 239338, 2391022
• CPC Class Codes: A61F 9/0008 Introducing ophthalmic products into the ocular cavity or retaining products therein putting in contact lenses A61F9/0061; introducing or retaining media in cavities of the body in general A61M31/00
• CPC Class Codes: A61F 9/0026 Ophthalmic product dispenser attachments to facilitate positioning near the eye
• CPC Class Codes: B05B 17/0607 generated by electrical means, e.g. piezoelectric transducers
• CPC Class Codes: B05B 17/0646 Vibrating plates, i.e. plates being directly subjected to the vibrations, e.g. having a piezoelectric transducer attached thereto
• CPC Class Codes: B05B 17/0661 Transducer materials

Abstract

An ejector device and method of delivering safe, suitable, and repeatable dosages to a subject for topical, oral, nasal, or pulmonary use is disclosed. The ejector device includes a housing, a reservoir disposed within the housing for receiving a volume of fluid, and an ejector mechanism in fluid communication with the reservoir and configured to eject a stream of droplets, the ejector mechanism comprising an ejector plate coupled to a generator plate and a piezoelectric actuator; the piezoelectric actuator being operable to oscillate the ejector plate, and thereby the generator plate, at a frequency and generate a directed stream of droplets.

Claims

1. A device for delivering a fluid to a target, the device comprising:

a housing;

a reservoir disposed within the housing for receiving a volume of fluid; and

an ejector mechanism in fluid communication with the reservoir and configured to eject a stream of droplets, the ejector mechanism comprising an ejector plate having a first surface in fluid communication with a fluid delivery area of the reservoir, and a second surface coupled to a polymeric generator plate and a piezoelectric actuator;

the polymeric generator plate having a first fluid intake surface coupled to the ejector plate and in fluid communication with a fluid delivery area of the reservoir, a second fluid exit surface, and a plurality of openings formed through its thickness, the plurality of openings having an average opening diameter at the second fluid exit surface of from about 20 μ

m to about 100 μ

m, which average opening diameter at the second fluid exit surface is smaller than the average opening diameter at the first fluid intake surface; and

the piezoelectric actuator being operable to oscillate the ejector plate, and thereby the polymeric generator plate, at a frequency and generate a directed stream of droplets;

wherein one or more of said plurality of openings are shaped so as to comprise a fluid entrance orifice, an entrance cavity, a capillary channel, and a fluid exit orifice, the capillary channel having a length in the range of from about 70 μ

m to about 120 μ

m.

2. The device of claim 1, wherein the plurality of openings are configured to provide desired three-dimensional geometry and shape and are formed via laser micromachining.

3. The device of claim 1, wherein the polymer generator plate is formed from a material selected from the group consisting of:

ultrahigh molecular weight polyethylene (UHMWPE), polyimide, polyether ether ketone (PEEK), talc-filled PEEK, polyvinylidine fluoride (PVDF), and polyetherimide.

4. The device of claim 1, wherein the ejector plate has a central open region aligned with the polymeric generator plate, and the piezoelectric actuator is coupled to a peripheral region of the ejector plate so as to not obstruct the plurality of openings of the polymeric generator plate.

5. The device of claim 4, wherein the plurality of openings of the polymeric generator plate are disposed in a center region of the polymeric generator plate that is uncovered by the piezoelectric actuator and aligned with the central open region of the ejector plate.

6. The device of claim 5, wherein the polymeric generator plate has a reduced size relative to the ejector plate, and the size of the polymeric generator plate is determined, at least in part, by the area occupied by the center region and the arrangement of the plurality of openings.

7. The device of claim 1, having an average ejected droplet diameter greater than 15 microns, the stream of droplets having low entrained airflow such that the stream of droplets deposit on a target during use.

8. An ejector mechanism configured to eject a stream of droplets, the ejector mechanism comprising:

an ejector plate having a first surface in fluid communication with a fluid delivery area of a reservoir, and a second surface coupled to a polymeric generator plate and a piezoelectric actuator;

the polymeric generator plate having a first fluid intake surface coupled to the ejector plate, a second fluid exit surface, and a plurality of openings formed through its thickness, the plurality of openings having an average opening diameter at the second fluid exit surface of from about 20 μ

m to about 100 μ

m, which average opening diameter at the second fluid exit surface is smaller than the average opening diameter at the first fluid intake surface; and

the piezoelectric actuator being operable to oscillate the ejector plate, and thereby the polymeric generator plate, at a frequency and generate a directed stream of droplets

wherein one or more of said plurality of openings are shaped so as to comprise a fluid entrance orifice, an entrance cavity, a capillary channel, and a fluid exit orifice, the capillary channel having a length in the range of from about 70 μ

m to about 120 μ

m.

9. The ejector mechanism of claim 8, wherein the polymer generator plate is formed from a material selected from the group consisting of:

ultrahigh molecular weight polyethylene (UHMWPE), polyimide, polyether ether ketone (PEEK), talc-filled PEEK, polyvinylidine fluoride (PVDF), and polyetherimide.

10. The ejector mechanism of claim 8, wherein the ejector plate has a central open region aligned with the polymeric generator plate, and the piezoelectric actuator is coupled to a peripheral region of the ejector plate so as to not obstruct the plurality of openings of the polymeric generator plate.

11. The ejector mechanism of claim 10, wherein the plurality of openings of the polymeric generator plate are disposed in a center region of the polymeric generator plate that is uncovered by the piezoelectric actuator and aligned with the central open region of the ejector plate.

12. The ejector mechanism of claim 11, wherein the polymeric generator plate has a reduced size relative to the ejector plate, and the size of the polymeric generator plate is determined, at least in part, by the area occupied by the center region and the arrangement of the plurality of openings.