Portable electrospinning device

• US 10,639,203 B2
• Filed: 05/11/2017
• Issued: 05/05/2020
• Est. Priority Date: 11/11/2014
• Status: Active Grant

• Current Assignee: Nanomedic Technologies, Ltd.
• Original Assignee: Nicast Ltd.
• Inventors: Dubson, Alexander
• Primary Examiner(s): Ochylski, Ryan M
• Application Number:
  US15/592,372
• Publication Number:
  US 20170239094A1
• Time in Patent Office: 1,090 Days
• CPC Class Codes: A61F 13/00063 comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic drug delivery dressings A61K9/70; chemical aspect of the additives A61L15/00
• CPC Class Codes: A61F 13/01017 synthetic, e.g. polymer based
• CPC Class Codes: B05B 5/007 the high voltage supplied to an electrostatic spraying apparatus during spraying operation being periodical or in time, e.g. sinusoidal
• CPC Class Codes: B05B 5/0538 the operator being part of a charge return path between target and apparatus
• CPC Class Codes: B05B 5/1691 Apparatus to be carried on or by a person or with a container fixed to the discharge device
• CPC Class Codes: D01D 5/003 the material being a polymer solution or dispersion D01D5/0053 takes precedence
• CPC Class Codes: D01D 5/0061 characterised by the electro-spinning apparatus
• CPC Class Codes: D01D 5/0084 Coating by electro-spinning, i.e. the electro-spun fibres are not removed from the collecting device but remain integral with it, e.g. coating of prostheses
• CPC Class Codes: D01D 5/0092 characterised by the electrical field, e.g. combined with a magnetic fields, using biased or alternating fields
• CPC Class Codes: D10B 2509/022 Wound dressings

Abstract

A handheld device for producing electrospun fibrous mat comprises: a housing configured to be handheld by a user; a container accommodating at least one electrospinning medium; at least a nozzle in fluid communication with the container; a mechanism dispensing the medium from the container via said nozzle; an auxiliary electrode surrounding the nozzle; and a power supply providing electric potentials to the nozzle and the auxiliary electrode. The housing comprises an electrically conductive portion configured to be gripped by the user during operation. The electrically conductive portion is connected to the power supply.

Claims

1. A handheld device for producing electrospun fibrous mat;

said device comprising;

a. a housing having at least one portion configured to be handheld by a user;

b. a container accommodating at least one electrospinning medium;

c. at least one nozzle in fluid communication with said container;

d. a mechanism dispensing said medium from said container via said nozzle;

e. an auxiliary electrode surrounding said nozzle;

f. a power supply providing difference of electric potentials on said nozzle and said auxiliary electrode;

wherein said housing comprises an electrically conductive portion configured to be gripped by said user during operation.

2. The device according to claim 1, wherein at least one of the following is true:

a. said auxiliary electrode is displaceable along said nozzle;

b. said auxiliary electrode has a shape selected from a group consisting of;

a circular barrel;

an oval barrel, a sphere, an ellipsoid and any combination thereof;

c. said dispensing mechanism comprises a piston exerting said container for squeezing out said electrospinning medium via said nozzle;

d. said container is selected from the group consisting of a carpule, a syringe, a barrel and any combination thereof,

e. said container and said nozzle are integrated into a single element;

f. at least one of said container and said nozzle is disposable,

g. said dispensing mechanism comprises a container bed configured for receiving said container when said electrospinning medium is squeezed from said container by said piston.

3. The device according to claim 1, wherein said container is at least partially made of a material pierceable by said nozzle when exerted by said piston to establish a fluid communication between said container and nozzle.

4. The device according to claim 3, wherein said container comprises at least two sealed compartments pierceable by said nozzle to feed content of said compartments to said nozzle.

5. The device according to claim 1, wherein at least one of the following is true:

a. said container comprises at least two compartments accommodating at least two electrospinning media;

said at least two media are mixable under deformation of said container;

b. said container comprises at least two sealed compartments successively pierceable by said nozzle to feed content of said compartments to said nozzle in a successive manner;

c. said container comprises at least two sealed compartments pierceable by at least two independent nozzles in parallel to feed content of said compartments in the same manner.

6. The device according to claim 1, wherein at least one of the following is true:

a. said power supply is of a unipolar type;

b. said power supply is provided with two spaced apart start buttons such that said device is gripped by both hands of an operator during operation thereof;

c. said device comprises means for positioning said device relative to a location of an electrospun fiber mat to be made;

d. said device comprises safety means deactivating said device when a distance between said nozzle and said surface to be coated is shorter than a predetermined value;

e. said electrically conductive portion is electrically connected to a surface to be coated by a conductive wire,

f. said electrically conductive portion is electrically connected to a neutral terminal of said power supply.

7. The device according to claim 1, wherein said unipolar power supply is configured for providing a potential selected from the group consisting of a positive potential, a negative potential and alternatively positive and negative potentials.

8. The device according to claim 1, wherein said positioning means comprises at least two laser light sources emitting light beam for marking a predetermined distance for producing an electrospun fiber mat.

9. The device according to claim 1, wherein said container comprises a barrel and a piston pressing out said at least one electrospinning medium into said nozzle.

10. The device according to claim 1, wherein said electric potential difference ranges between 5 kV to 50 kV.

11. The device according to claim 10, wherein said electric potential difference is between 20 kV to 30 kV.

12. The device according to claim 1, wherein said fibrous mat comprises at least two layers made of different electrospinning media.

13. The device according to claim 1, wherein a flow rate per said nozzle ranges between 1 ml/hour to 20 ml/hour.

14. The device according to claim 13, wherein a flow rate per said nozzle ranges between 5 ml/hour to 10 ml/hour.

15. The device according to claim 1, wherein said electrospinning medium comprises at least one pharmaceutical agent.