Method for inhibiting or masking fishy odours

• US 10,639,251 B2
• Filed: 10/28/2015
• Issued: 05/05/2020
• Est. Priority Date: 10/28/2015
• Status: Active Grant

• Current Assignee: Symrise AG
• Original Assignee: Symrise AG
• Inventors: Hatt, Hanns, Gisselmann, Gunter, Wallrabenstein, Ivonne, Singer, Marco, Panten, Johannes
• Primary Examiner(s): Palenik, Jeffrey T.
• Application Number:
  US15/770,950
• Publication Number:
  US 20180318189A1
• Time in Patent Office: 1,651 Days
• Field of Search: None
• CPC Class Codes: A61K 8/342 Alcohols having more than seven atoms in an unbroken chain
• CPC Class Codes: A61Q 13/00 Formulations or additives for perfume preparations essential oils or perfumes per se C11B9/00
• CPC Class Codes: C11B 9/0019 carbocylic acids; Salts or esters thereof
• CPC Class Codes: G01N 2500/04 Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
• CPC Class Codes: G01N 33/5041 involving analysis of members of signalling pathways
• CPC Class Codes: G01N 33/566 using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds

Abstract

Norlimbanol in general and particularly its isomer mixture Timberol®, an amber-woody fragrance, is able to specifically inhibit the trimethylamine-induced h TAAR5 activation up to 96%. Moreover, human psychophysical data showed that the presence of Timberol® increases the olfactory detection threshold for the characteristic fishy odor of trimethylamine by almost one order of magnitude.

Claims

1. A method for masking or reducing fish odour caused by tertiary methyl amine generated by humans or other mammals, by blocking hTAAR5 receptors, comprising the following steps:

(a) providing a composition consisting of at least one isomer according to formula (Ia) and (Ib)

2. The method of claim 1, wherein said composition is a fragrance or an air refresher.

3. The method of claim 1, wherein said composition is a cosmetic or personal care composition.

4. A method for blocking human TAAR5 receptors and suppressing murine-mediated TAAR5-responses to tertiary methyl amine, comprising the following steps:

(a) providing a composition consisting of at least one isomer according to formula (Ia) and (Ib)