Multi-functional echogenic immunoliposomes for directed stem cell delivery to atheroma
First Claim
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1. A method of treating atherosclerosis in a patient, wherein said treating comprises:
- delivering to an atherosclerotic lesion;
(i) a CD34-positive stem cell; and
(ii) an echogenic liposome comprising;
(a) at least one ultrasound reflective material; and
(b) at least a first and second antibody attached to said liposome, wherein said first antibody is an anti-CD34 antibody that binds to the CD34 on the CD34-positive stem cell, wherein said second antibody is an anti-ICAM antibody that localizes said liposome to said atherosclerotic lesion, and wherein said liposome responds to an ultrasound stimulus, thereby localizing said CD34-positive stem cell to said lesion and stabilizing said lesion,wherein said liposome is formulated to release a stem cell enhancing agent selected from the group consisting of;
antibodies, drugs, genes, and combinations thereof, in response to an ultrasound releasing stimulus.
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Abstract
Disclosed are multifunctional-echogenic immunoliposome (MF-ELIP) constructs and compositions, and their methods of use to deliver attached stem cells to a target tissue such as atheroma, to enhance one or more of survival, growth, migration, activity and differentiation of the targeted stem cells, for treating, deterring or preventing mammalian atheroma and coronary artery disease.
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7 Claims
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1. A method of treating atherosclerosis in a patient, wherein said treating comprises:
delivering to an atherosclerotic lesion; (i) a CD34-positive stem cell; and (ii) an echogenic liposome comprising; (a) at least one ultrasound reflective material; and (b) at least a first and second antibody attached to said liposome, wherein said first antibody is an anti-CD34 antibody that binds to the CD34 on the CD34-positive stem cell, wherein said second antibody is an anti-ICAM antibody that localizes said liposome to said atherosclerotic lesion, and wherein said liposome responds to an ultrasound stimulus, thereby localizing said CD34-positive stem cell to said lesion and stabilizing said lesion, wherein said liposome is formulated to release a stem cell enhancing agent selected from the group consisting of;
antibodies, drugs, genes, and combinations thereof, in response to an ultrasound releasing stimulus.- View Dependent Claims (2, 3, 4, 5, 6, 7)
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