Process for preparation of bioavailable white curcumin—a unique blend of hydrogenated curcuminoids
First Claim
1. A composition of a white curcumin with enhanced bioavailability, wherein the white curcumin comprises a mixture of 75-80% tetrahydrocurcuminoids, 15-20% hexahydrocurcuminoids and 3-5% octahydrocurcuminoids, wherein the white curcumin is synthesized by palladium carbon catalyzed hydrogenation of purified curcuminoids obtained from Curcuma longa.
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Abstract
The present invention discloses a process for preparation of white curcumin from purified curcuminoids. The curcuminoids are obtained by solvent extraction and crystallization of dried turmeric powder. The autoclave is charged with ethyl acetate and the 95% purity curcuminoids mixture is added to and stirred for uniformity at room temperature. 5% (w/w) of 10% palladium carbon is added to the reaction mixture and allowed for hydrogenation in the presence of hydrogen gas at 2 lbps pressure and stirred continuously for 15 hours. Once the reaction is completed, the reaction mixture is filtered and washed with ethyl acetate. The ethyl acetate is distilled off and crude mass is stirred with water to obtain a solid precipitate. Finally, the solid obtained is filtered and dried to pale brown crystals of white curcumin. White curcumin is encapsulated with beta-cyclodextrin, which exhibited increased bioavailability. White curcumin also exhibited anti-oxidant and chemopreventive activities.
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- 1. A composition of a white curcumin with enhanced bioavailability, wherein the white curcumin comprises a mixture of 75-80% tetrahydrocurcuminoids, 15-20% hexahydrocurcuminoids and 3-5% octahydrocurcuminoids, wherein the white curcumin is synthesized by palladium carbon catalyzed hydrogenation of purified curcuminoids obtained from Curcuma longa.
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