Anti-aging skin care compositions and regimens

• US 10,639,288 B2
• Filed: 09/11/2015
• Issued: 05/05/2020
• Est. Priority Date: 09/12/2014
• Status: Active Grant

• Current Assignee: The Procter & Gamble Company
• Original Assignee: The Procter & Gamble Company
• Inventors: Tamura, Makio, Osborne, Rosemarie, Rocchetta, Heather Lynn
• Primary Examiner(s): Vu, Jake M
• Application Number:
  US14/851,418
• Publication Number:
  US 20160074301A1
• Time in Patent Office: 1,698 Days
• Field of Search: None
• CPC Class Codes: A23L 29/10 containing emulsifiers
• CPC Class Codes: A23L 33/12 Fatty acids or derivatives thereof
• CPC Class Codes: A23L 33/30 Dietetic or nutritional methods, e.g. for losing weight A23L33/10 takes precedence
• CPC Class Codes: A23L 33/40 Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A61K 2800/20 Chemical, physico-chemical or functional or structural properties of the composition as a whole
• CPC Class Codes: A61K 2800/48 Thickener, Thickening system
• CPC Class Codes: A61K 2800/884 Sequential application
• CPC Class Codes: A61K 31/202 having three or more double bonds, e.g. linolenic eicosanoids, e.g. leukotrienes A61K31/557
• CPC Class Codes: A61K 35/60 Fish, e.g. seahorses; Fish eggs
• CPC Class Codes: A61K 49/0006 Skin tests, e.g. intradermal testing, test strips, delayed hypersensitivity
• CPC Class Codes: A61K 8/062 Oil-in-water emulsions
• CPC Class Codes: A61K 8/31 Hydrocarbons
• CPC Class Codes: A61K 8/342 Alcohols having more than seven atoms in an unbroken chain
• CPC Class Codes: A61K 8/345 containing more than one hydroxy group
• CPC Class Codes: A61K 8/368 with carboxyl groups directly bound to carbon atoms of aromatic rings
• CPC Class Codes: A61K 8/37 Esters of carboxylic acids
• CPC Class Codes: A61K 8/585 Organosilicon compounds
• CPC Class Codes: A61K 8/64 Proteins; Peptides; Derivatives or degradation products thereof
• CPC Class Codes: A61K 8/67 Vitamins
• CPC Class Codes: A61K 8/9789 : Magnoliopsida [dicotyledons]
• CPC Class Codes: A61K 9/0029 : Parenteral nutrition; Parenteral nutrition compositions as drug carriers
• CPC Class Codes: A61K 9/107 : Emulsions ; Emulsion preconcentrates; Micelles composition of emulsions A61K47/00
• CPC Class Codes: A61Q 19/08 : Anti-ageing preparations

Abstract

Multi-step cosmetic regimens are provided to improve the appearance of aging skin. A target portion of skin that exhibits a sign of skin aging is identified. A first formulation is topically applied, comprising at least one active possessing an ability to transcriptionally up-regulate an eigengene derived from a genetic co-expression module for one or more biological themes associated with skin cleansing and/or skin detoxification, and/or skin hydration to the target portion of skin. A second formulation is also topically applied, comprising at least one active possessing an ability to transcriptionally up-regulate an eigengene derived from a co-expression module for one or more biological themes associated with skin repair and/or rebuilding to the target portion of skin.

Claims

1. A method for identifying an agent effective for transcriptionally up-regulating an eigengene associated with a desirable cosmetic phenotype of human skin, the method comprising:

deriving an eigengene for a co-expression module determined from a set of genes transcriptionally up-regulated in human skin exhibiting the desirable cosmetic phenotype and a set of genes associated with a clean and detox biological theme selected from the group consisting of protein catabolic process, regulation of autophagy, regulation of endopeptidase activity, and regulation of proteolysis;

treating skin with a putative agent;

conducting a transcriptional assessment of the eigengene in the treated skin; and

identifying the putative agent as an effective clean and detox agent if the eigengene is up-regulated in the treated skin.

2. The method of claim 1, further comprising deriving a second eigengene for a co-expression module determined from a set of genes transcriptionally up-regulated in human skin exhibiting the desirable cosmetic phenotype and a set of genes associated with a cell repair and rebuild biological theme selected from the group consisting of amino sugar biosynthetic process, cell adhesion junction, deoxyribonucleic acid repair, glycerolipid metabolic process, response to growth factor stimulus, ribonucleic acid processing, and Wnt receptor signaling pathway;

treating skin with the putative agent;

conducting a transcriptional assessment of the second eigengene in the treated skin;

and identifying the putative agent as an effective cell repair and rebuilding agent if the second eigengene is up-regulated in the treated skin.