Methods for increasing blood plasma 2′-deoxyuridine (dUrd) and thymidylate synthase inhibition
First Claim
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1. A method comprising:
- a. a step of administering 400 mg/m2 5-fluorouracil (5-FU) intravenously as a bolus injection to a human subject;
b. a step of administering 60, 120, 240 mg/m2 [6R]-5,10-methylene tetrahydrofolate (6R-MTHF) intravenously as two bolus injections to said human subject approximately 30 minutes and 60 minutes following step (a); and
c. a step of administering 2400 mg/m2 5-FU as a continuous infusion, either simultaneously with or following step (b).
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Abstract
The present invention provides methods for increasing plasma dUrd levels comprising the administration of 6R-MTHF. The methods of increasing plasma dUrd increase dUrd levels compared to equimolar concentrations of LV. The present invention also provides methods for increasing TS inhibition comprising the administration of 6R-MTHF. The present invention also provides methods for increasing TS inhibition comprising the administration of 6R-MTHF.
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Citations
13 Claims
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1. A method comprising:
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a. a step of administering 400 mg/m2 5-fluorouracil (5-FU) intravenously as a bolus injection to a human subject; b. a step of administering 60, 120, 240 mg/m2 [6R]-5,10-methylene tetrahydrofolate (6R-MTHF) intravenously as two bolus injections to said human subject approximately 30 minutes and 60 minutes following step (a); and c. a step of administering 2400 mg/m2 5-FU as a continuous infusion, either simultaneously with or following step (b). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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Specification