Pediatric nutritional composition with milk peptides for healthy growth and development

• US 10,639,334 B2
• Filed: 01/07/2014
• Issued: 05/05/2020
• Est. Priority Date: 01/07/2014
• Status: Active Grant

• Current Assignee: Mead Johnson Nutrition Company (Reckitt Benckiser Group PLC)
• Original Assignee: Mead Johnson Nutrition Company (Reckitt Benckiser Group PLC)
• Inventors: Banavara, Dattatreya, Batema, Roseanne P.
• Primary Examiner(s): Alstrum-Acevedo, James H
• Assistant Examiner(s): Martinez, Tara L
• Application Number:
  US14/149,424
• Publication Number:
  US 20150189905A1
• Time in Patent Office: 2,310 Days
• Field of Search: None
• CPC Class Codes: A23L 33/12 Fatty acids or derivatives thereof
• CPC Class Codes: A23L 33/13 Nucleic acids or derivatives thereof A23L33/145 takes precedence
• CPC Class Codes: A23L 33/135 Bacteria or derivatives thereof, e.g. probiotics
• CPC Class Codes: A23L 33/145 Extracts
• CPC Class Codes: A23L 33/18 Peptides; Protein hydrolysates
• CPC Class Codes: A23L 33/19 Dairy proteins
• CPC Class Codes: A23L 33/21 Addition of substantially indigestible substances, e.g. dietary fibres
• CPC Class Codes: A23L 33/40 Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/304 having a modulation effect on allergy and risk of allergy
• CPC Class Codes: A23V 2200/31 having an effect on comfort perception and well-being
• CPC Class Codes: A23V 2200/324 having an effect on the immune system
• CPC Class Codes: A23V 2250/1868 Docosahexaenoic acid
• CPC Class Codes: A23V 2250/51 Polysaccharide
• CPC Class Codes: A23V 2250/5424 Dairy protein
• CPC Class Codes: A23V 2250/54242 Alpha lactalbumin
• CPC Class Codes: A23V 2250/54244 Beta lactoglobulin
• CPC Class Codes: A23V 2250/54246 Casein
• CPC Class Codes: A23V 2250/54248 Lactoferrin
• CPC Class Codes: A23V 2250/55 Peptide, protein hydrolysate
• CPC Class Codes: A61K 2300/00 : Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/202 : having three or more double bonds, e.g. linolenic eicosanoids, e.g. leukotrienes A61K31/557
• CPC Class Codes: A61K 35/20 : Milk; Whey; Colostrum
• CPC Class Codes: A61K 38/018 : from milk
• CPC Class Codes: A61K 45/06 : Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

The present disclosure generally provides pediatric nutritional compositions comprising a protein source comprising an intact milk protein and a partially hydrolyzed milk protein, wherein about 5% to about 25% of total nitrogen content of the composition is non-protein nitrogen. The pediatric nutritional compositions described herein also comprise a fat source and a carbohydrate source. The partially hydrolyzed protein source, in certain embodiments, provides peptides that have similar structure and function to the peptides found in human milk.

Claims

1. A nutritional composition comprising:

a protein source comprising an intact milk protein and a partially hydrolyzed milk protein comprising peptides having a molecular weight of less than 10 kDa,

wherein the intact milk protein is present in an amount of from about 1.35 g per 100 kcal to about 2.85 g per 100 kcal and the peptides having a molecular weight of less than 10 kDa are present in an amount of from about 0.09 g per 100 kcal to about 0.75 g per 100 kcal, and

further wherein the partially hydrolyzed milk protein includes each of the following individual peptides derived from β

-lactoglobulin SEQ ID No. 3, SEQ ID No. 4, SEQ ID No. 5, and SEQ ID No. 8,

a fat source, and

a carbohydrate source,

wherein the intact milk protein comprises whey and casein having a whey to casein weight ratio ranging from about 80;

20 to 50;

50.

2. The composition of claim 1, wherein about 5% to about 25% of the total nitrogen content of the composition is provided by peptides in the partially hydrolyzed protein.

3. The composition of claim 1, wherein the hydrolyzed milk protein has a degree of hydrolysis ranging from about 4% to about 40%.

4. The composition of claim 1, wherein at least 75% by weight of the peptides have a molecular weight of less than 5 kDa.

5. The composition of claim 1, wherein the partially hydrolyzed milk protein comprises additional peptides derived from β

-casein, α

-S1-casein, κ

-casein, α

-lactalbumin, β

-lactoglobulin, IL-2, TGF-β

, IGF-1, GLYCAM-1, SPDR protein, and combinations thereof.

6. The nutritional composition of claim 1, wherein the partially hydrolyzed milk protein comprises at least five additional individual peptides selected from the group consisting of SEQ ID No. 10, SEQ ID No. 11, SEQ ID No. 12, SEQ ID No. 13, SEQ ID No. 14, SEQ ID No. 15, SEQ ID No. 16, SEQ ID No. 17, SEQ ID No. 18, SEQ ID No. 19, SEQ ID No. 20, SEQ ID No. 21, SEQ ID No. 22, SEQ ID No. 23, SEQ ID No. 24, SEQ ID No. 25, SEQ ID No. 26, SEQ ID No. 27, SEQ ID No. 28, SEQ ID No. 29, SEQ ID No. 30, SEQ ID No. 31, SEQ ID No. 32, SEQ ID No. 33, SEQ ID No. 34, SEQ ID No. 35, SEQ ID No. 36, SEQ ID No. 37, SEQ ID No. 38, SEQ ID No. 39, SEQ ID No. 40, SEQ ID No. 41, SEQ ID No. 42, SEQ ID No. 43, SEQ ID No. 44, SEQ ID No. 45, SEQ ID No. 46, SEQ ID No. 47, SEQ ID No. 48, SEQ ID No. 49, SEQ ID No. 50, SEQ ID No. 51, SEQ ID No. 52 and SEQ ID No 53.

7. The composition of claim 6, wherein the peptide has antioxidant activity, antimicrobial activity, immunomodulatory activity, acetyl choline transferase (ACE) inhibitory activity, or a combination thereof.

8. The composition of claim 1, wherein the peptides provide at least 5 mM Trolox equivalent antioxidant capacity to the composition.

9. The nutritional composition of claim 1, wherein the composition is an infant formula.

10. The composition of claim 1, further comprising a prebiotic.

11. The composition of claim 1, further comprising a source of docosahexaenoic acid.

12. The composition of claim 1, wherein the intact protein comprises about 75 to about 95% of the total nitrogen content of the composition.

13. The composition of claim 1, wherein less than 5% of the non-protein nitrogen in the composition comprises nucleotides, carnitine, lecithin or mixtures thereof.

14. The composition of claim 1, wherein about 5% to about 25% of total nitrogen content of the composition is non-protein nitrogen provided by the partially hydrolyzed milk protein.

15. The composition of claim 1, wherein the partially hydrolyzed protein further comprises at least one peptide selected from the group consisting of SEQ ID NO 1, SEQ ID NO 2, SEQ ID NO 6, SEQ ID NO 7, and SEQ ID NO 9.

16. The composition of claim 1, further comprising choline.