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Compositions for preserving photoreceptor cells, retinal pigment epithelial cells, or visual function

  • US 10,639,345 B2
  • Filed: 10/26/2018
  • Issued: 05/05/2020
  • Est. Priority Date: 04/23/2010
  • Status: Active Grant
First Claim
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1. A composition for preserving the viability of photoreceptor cells, preserving the viability of retinal pigment epithelial cells, or preserving or improving visual function in an eye of a subject with retinal detachment, the composition comprising:

  • a pharmaceutically acceptable carrier, a necrostatin and an apoptosis inhibitor,wherein the apoptosis inhibitor is selected from the group consisting of a pan-caspase inhibitor, a caspase-1 inhibitor, a caspase-3 inhibitor, a caspase-8 inhibitor, and a caspase-9 inhibitor, andwherein the necrostatin is selected from the group consisting of;

    (i) a Nec-1 related compound of Formula I;

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