BCMA chimeric antigen receptors
First Claim
Patent Images
1. A population of cells comprising T cells, wherein the T cells comprise a lentiviral vector comprising a left (5′
- ) lentiviral LTR;
a Psi (Ψ
) packaging signal;
a central polypurine tract/DNA flap (cPPT/FLAP);
a retroviral export element;
a promoter operably linked to a polynucleotide sequence encoding a chimeric antigen receptor (CAR), wherein the polynucleotide sequence is set forth in SEQ ID NO;
10; and
a right (3′
) lentiviral LTR.
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Abstract
The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.
66 Citations
21 Claims
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1. A population of cells comprising T cells, wherein the T cells comprise a lentiviral vector comprising a left (5′
- ) lentiviral LTR;
a Psi (Ψ
) packaging signal;
a central polypurine tract/DNA flap (cPPT/FLAP);
a retroviral export element;
a promoter operably linked to a polynucleotide sequence encoding a chimeric antigen receptor (CAR), wherein the polynucleotide sequence is set forth in SEQ ID NO;
10; and
a right (3′
) lentiviral LTR. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
- ) lentiviral LTR;
-
12. A population of cells comprising immune effector cells, wherein the immune effector cells comprise a lentiviral vector, wherein the lentiviral vector comprises a left (5′
- ) lentiviral LTR wherein the promoter of the 5′
LTR is replaced with a CMV promoter;
a Psi (Ψ
) packaging signal;
a cPPT/FLAP;
a Rev response element (RRE);
a myeloproliferative sarcoma virus enhancer, negative control region deleted, dl587rev primer-binding site substituted (MND) promoter operably linked to a polynucleotide sequence encoding a CAR, wherein the polynucleotide sequence is set forth in SEQ ID NO;
10;
a right (3′
) lentiviral self-inactivating (SIN) LTR; and
a heterologous polyadenylation sequence. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21)
- ) lentiviral LTR wherein the promoter of the 5′
Specification