Use of inactivated nonreplicating modified vaccinia virus Ankara (MVA) as monoimmunotherapy or in combination with immune checkpoint blocking agents for solid tumors
First Claim
1. A method for treating a solid malignant tumor in a subject in need thereof, the method comprising delivering to cells of the tumor a therapeutically effective amount of inactivated modified vaccinia Ankara virus (inactivated-MVA), thereby resulting in treatment of the tumor, wherein the inactivated-MVA is heat-inactivated MVA, wherein the tumor is primary or metastatic melanoma, primary or metastatic colon carcinoma, or primary or metastatic breast cancer.
2 Assignments
0 Petitions
Accused Products
Abstract
The present disclosure relates to infection-competent, but nonreplicative inactivated modified vaccinia Ankara (MVA) and its use as immunotherapy, alone, or in combination with immune checkpoint blocking agents for the treatment of malignant solid tumors. Particular embodiments relate to inducing an immune response in a subject diagnosed with a solid malignant tumor.
92 Citations
16 Claims
- 1. A method for treating a solid malignant tumor in a subject in need thereof, the method comprising delivering to cells of the tumor a therapeutically effective amount of inactivated modified vaccinia Ankara virus (inactivated-MVA), thereby resulting in treatment of the tumor, wherein the inactivated-MVA is heat-inactivated MVA, wherein the tumor is primary or metastatic melanoma, primary or metastatic colon carcinoma, or primary or metastatic breast cancer.
- 8. A method for treating a solid malignant tumor in a subject in need thereof, the method comprising delivering to tumor cells of the subject a therapeutically effective amount of inactivated modified vaccinia Ankara virus (inactivated-MVA) and conjointly administering to the subject a therapeutically effective amount of an immune checkpoint blocking agent, wherein the inactivated-MVA is heat-inactivated MVA, wherein the tumor is primary or metastatic melanoma, primary or metastatic colon carcinoma, or primary or metastatic breast cancer.
Specification