Insert and drug delivery device herewith

• US 10,639,428 B2
• Filed: 10/09/2015
• Issued: 05/05/2020
• Est. Priority Date: 10/09/2014
• Status: Active Grant

• Current Assignee: Sanofi
• Original Assignee: Sanofi
• Inventors: Morris, Anthony Paul
• Primary Examiner(s): Gilbert, Andrew M
• Application Number:
  US15/517,251
• Publication Number:
  US 20170304554A1
• Time in Patent Office: 1,670 Days
• CPC Class Codes: A61M 2005/2026 Semi-automatic, e.g. user activated piston is assisted by additional source of energy
• CPC Class Codes: A61M 2005/3126 Specific display means related to dosing
• CPC Class Codes: A61M 2205/58 Means for facilitating use, e.g. by people with impaired vision
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/31528 by means of rotational movements, e.g. screw-thread mechanisms
• CPC Class Codes: A61M 5/31541 Means preventing setting of a dose beyond the amount remaining in the cartridge
• CPC Class Codes: A61M 5/31553 without axial movement of dose setting member
• CPC Class Codes: A61M 5/31583 based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
• CPC Class Codes: A61M 5/31593 Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir

Abstract

The present disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament and to an insert for such a device. The insert comprises a cup-shaped body with a distal end and a proximal end. The body has a sidewall and a tube which extends centrally through the cup-shaped body in a longitudinal direction, thereby defining an annular space between the sidewall and the tube. The annular space is open in the proximal direction for receiving a compression spring. The tube comprises a thread provided at an inner surface of the tube. Further, the tube, the sidewall and/or a second part comprise a clutch feature for rotationally constraining a component part to the insert.

Claims

1. A drug delivery device for selecting and dispensing a number of user variable doses of a medicament, the drug delivery device comprising:

a housing,

a cartridge holder,

a cartridge containing a medicament,

a piston rod,

a drive member,

a compression spring, and

an insert comprising;

a first part having a cup-shaped body with a distal end and a proximal end, the body having a sidewall,

a tube extending centrally through the cup-shaped body in a longitudinal direction defining an annular space between the sidewall and the tube, wherein the annular space is open in the proximal end direction for receiving the compression spring, wherein the tube comprises a thread for engaging an outer thread of the piston rod, the thread being provided at an inner surface of the tube, and wherein at least one of the tube, the sidewall, and a separate second part of the insert comprises a first clutch feature for rotationally constraining the drive member to the insert, and

at least one arm extending radially outwards from the sidewall, wherein the at least one arm is configured to lock the first part of the insert to the housing for rotationally and axially constraining the insert to the housing, or the first part of the insert is integrally connected to the housing by the at least one arm to form one single component part with the housing.

2. The drug delivery device according to claim 1, wherein the annular space between the sidewall and the tube defines a portion for receiving or guiding the drive member, the drive member being axially displaceable.

3. The drug delivery device according to claim 1, wherein the cup-shaped body comprises a radially extending bottom wall closing the annular space at the distal end.

4. The drug delivery device according to claim 1, wherein the first part is integrally formed with the housing of the drug delivery device and wherein the separate second part is axially or rotationally constrained to the first part or the housing of the drug delivery device.

5. The drug delivery device according to claim 4, wherein the first part comprises the sidewall and the tube with the thread, and wherein the second part comprises the first clutch feature.

6. The drug delivery device according to claim 4, further comprising a drive spring, wherein a proximal end of the sidewall, the at least one arm or the second part comprises an opening that receives a hook end of the drive spring.

7. The drug delivery device according to claim 1, further comprising at least one member selected from the group consisting of:

a nut,

a dose setting element,

a button,

a dose setting grip,

a gauge element, and

a clutch plate.

8. The drug delivery device according to claim 1, wherein the piston rod has an outer diameter equal to or smaller than an inner diameter of the tube of the insert.

9. The drug delivery device according to claim 1, wherein the drive member is an axially displaceable tubular element at least partly surrounding the piston rod, wherein a distal end of the drive member has an inner diameter equal to or larger than an outer diameter of the tube of the insert and the drive member has an outer diameter equal to or smaller than an inner diameter of the sidewall of the insert.

10. The drug delivery device according to claim 1, wherein the drive member comprises axially extending splines provided at an outer surface of the drive member, and wherein the first clutch feature for rotationally constraining the drive member to the insert comprises axially extending splines provided at an inner surface of the sidewall of the insert or on the second part.

11. The drug delivery device according to claim 1, wherein the compression spring located within the annular space interposed between the insert and a drive member is a clutch spring.

12. The drug delivery device according to claim 1, wherein the drive spring is in the form of a torsion spring having at least one hook configured to engage an opening of the insert, the at least one hook being at a distal end of the torsion spring.

13. The drug delivery device according to claim 4, further comprising a drive spring, wherein a proximal end of the sidewall, the at least one arm and the second part, and the second part defines an opening that receives a hook end of the drive spring.