Magnetic mixer and method

• US 10,639,602 B2
• Filed: 07/28/2017
• Issued: 05/05/2020
• Est. Priority Date: 07/28/2016
• Status: Active Grant

• Current Assignee: MediSieve Ltd.
• Original Assignee: MediSieve Ltd.
• Inventors: Frodsham, George Charles Martin, Pankhurst, Quentin Andrew
• Primary Examiner(s): Sorkin, David L
• Application Number:
  US15/662,446
• Publication Number:
  US 20180028990A1
• Time in Patent Office: Days
• Field of Search: 366273, 366274, 417420
• CPC Class Codes: B01F 2101/2204 Mixing chemical components in generals in order to improve chemical treatment or reactions, independently from the specific application
• CPC Class Codes: B01F 27/50 Pipe mixers, i.e. mixers wherein the materials to be mixed flow continuously through pipes, e.g. column mixers
• CPC Class Codes: B01F 33/451 wherein the mixture is directly exposed to an electromagnetic field without use of a stirrer, e.g. for material comprising ferromagnetic particles or for molten metal
• CPC Class Codes: B01F 35/221422 Speed of rotation of the mixing axis, stirrer or receptacle during the operation
• CPC Class Codes: B01F 35/3204 Motor driven, i.e. by means of an electric or IC motor
• CPC Class Codes: B03C 1/01 by addition of magnetic adjuvants
• CPC Class Codes: B03C 1/02 acting directly on the substance being separated
• CPC Class Codes: B03C 1/0332 using permanent magnets
• CPC Class Codes: B03C 1/0335 using coils
• CPC Class Codes: B03C 1/288 disposed at the outer circumference of a recipient
• CPC Class Codes: B03C 1/30 Combinations with other devices, not otherwise provided for
• CPC Class Codes: B03C 2201/18 Magnetic separation whereby the particles are suspended in a liquid
• CPC Class Codes: B03C 2201/26 for use in medical applications
• CPC Class Codes: H01F 7/0231 Magnetic circuits with PM for power or force generation
• CPC Class Codes: H02P 8/14 Arrangements for controlling speed or speed and torque H02P8/12, H02P8/22 take precedence

Abstract

A molecular mixing system. In one embodiment, the molecular mixing system includes a motorized turntable; a speed controller to control the rotational speed of the motorized turntable; a plurality of magnets arranged in a first Halbach array, the first Halbach array located on the motorized turntable and concentric to the axis of the motorized turntable; and a sample conduit having an input port and an output port and having an outer wall defining a lumen, the sample conduit positioned within and concentric with the first Halbach array.

Claims

1. A system for capturing target components from a liquid, comprising:

a motorized turntable;

a speed controller to control rotational velocity of the motorized turntable;

a plurality of magnets arranged in a first Halbach array, the first Halbach array located on the motorized turntable and concentric with the axis of the motorized turntable so as to rotate circumferentially about the outer circumference of a sample conduit,

the sample conduit having an input port and an output port and having an outer wall defining a lumen, the sample conduit positioned within the opening and concentric with the axis of the first Halbach array; and

a liquid flowing through the sample conduit from the input port to the output port, the liquid containing chains of magnetic particles and one or more chemical agents attached to the chains for capturing said target components from the liquid.

2. The system of claim 1 wherein the fluid further comprises a plurality of magnetic nanoparticles.

3. The system of claim 1 wherein the one or more chemical agents comprise a ligand attached to the magnetic particles.

4. The system of claim 2 wherein the one or more chemical agents comprise a ligand attached to at least one of the magnetic particles and the magnetic nanoparticles.

5. The system of claim 1 wherein the sample conduit comprises a sample container.

6. The system of claim 5 wherein the sample container comprises an inner wall concentric with the outer wall and defining a lumen between the inner and outer wall, the lumen in fluid communication with the input and output ports.

7. The system of claim 6 wherein the system comprises a second Halbach array of magnets within the inner wall of the sample container.

8. The system of claim 1 wherein the first Halbach array has a K=2.

9. The system of claim 7 wherein the second Halbach array has a K=1.

10. The system of claim 5 wherein the sample container has a truncated conical shape with the largest portion of the cone at the input port and the narrowest portion of the cone at the output port.

11. The system of claim 1 wherein the Halbach array comprises a plurality of Halbach arrays stacked axially adjacent to one another and separated by a space.

12. The system of claim 11 wherein the plurality of Halbach arrays have varying heights and are stacked from the greatest height to the smallest height from input port to output port.

13. A system for capturing target components from a liquid comprising:

a sample conduit having an input port and an output port and having an outer wall defining a lumen;

a motorized carrier;

a speed controller to control the rotational speed of the motorized carrier;

a pair of electromagnets attached to the motorized carrier and positioned on opposite sides of the sample conduit;

so as to

rotates circumferentially about the outer circumference of the sample conduit; and

a liquid flowing through the sample conduit from the input port to the output port, the liquid containing chains of magnetic particles and one or more chemical agents attached to the chains for capturing said target components from the liquid.

14. The system of claim 13, wherein the pair of electromagnetics are oriented such that poles of each electromagnetic in the pair have opposite polarity.

15. The system of claim 13, wherein the liquid further comprises a plurality of magnetic nanoparticles, and the one or more chemical agents comprise a ligand attached to at least one of the magnetic particles and the magnetic nanoparticles.

16. The system of claim 13, wherein rotation of the pair of electromagnets rotates the magnetic field about an axis coaxial with the longitudinal axis of the sample conduit with an angular velocity, the strength of the magnetic field and the angular velocity of rotation adjusted such that the magnetic particles form the chains of magnetic particles, the one or more chemical agents being attached to the chains, so as to capture on the chains the target components from the liquid.