Gnetin C-rich melinjo extract and production method thereof

• US 10,640,480 B2
• Filed: 07/28/2017
• Issued: 05/05/2020
• Est. Priority Date: 07/28/2017
• Status: Active Grant

• Current Assignee: Hosoda SHC Co., Ltd., Perkumpulan Melingo Indonesia
• Original Assignee: Hosoda SHC Co., Ltd.
• Inventors: Kato, Eishin, Hosoda, Shinya
• Primary Examiner(s): Mi, Qiuwen
• Application Number:
  US15/579,770
• Publication Number:
  US 20190031635A1
• Time in Patent Office: 1,012 Days
• Field of Search: None
• CPC Class Codes: A23L 33/105 Plant extracts, their artificial duplicates or their derivatives
• CPC Class Codes: A61K 2236/00 Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
• CPC Class Codes: A61K 36/17 Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
• CPC Class Codes: A61K 8/9778 Gnetophyta, e.g. Ephedraceae [Mormon-tea family]
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 19/06 Antigout agents, e.g. antihyperuricemic or uricosuric agents
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 3/06 Antihyperlipidemics
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 35/02 specific for leukemia
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 37/06 Immunosuppressants, e.g. drugs for graft rejection
• CPC Class Codes: A61P 9/12 Antihypertensives
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations
• CPC Class Codes: C07D 307/80 Radicals substituted by oxygen atoms

Abstract

To provide a gnetin C high content melinjo extract rich in the content of gnetin C which is useful for prevention and/or treatment of diseases such as metabolic syndrome, diabetes mellitus, hypertension, gout, cancer, collagen disease, periodontal disease and the like and further for beauty care and/or protection of skin and of which intake/dosage or use amount can be reduced. An extract is extracted from melinjo fruit, by using an extraction solvent which is a mixed solvent obtained by blending at least one of an emulsifier, a cycrodextrin and an acid into water and/or an organic solvent.

Claims

1. A production method of a melinjo extract, comprising an extraction step of extracting an extract from melinjo fruit by using an extraction solvent which is a mixed solvent obtained by blending at least one of an emulsifier, a cycrodextrin and an acid into water and/or an organic solvent, and a temperature of the extraction solvent in extracting is 10 to 70°

C.

2. The production method according to claim 1, wherein the melinjo fruit is melinjo endosperm.

3. The production method according to claim 1, wherein the organic solvent is one or more selected from ethanol, ethyl acetate and acetone.

4. The production method according to claim 1, wherein the emulsifier is one or more selected from glycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, soybean lecithin and sodium stearate.

5. The production method according to claim 1, wherein the acid is one or more selected from acetic acid, lactic acid, citric acid, adipic acid, hydrochloric acid and phosphoric acid.

6. The production method according to claim 2, wherein the organic solvent is one or more selected from ethanol, ethyl acetate and acetone.

7. The production method according to claim 2, wherein the emulsifier is one or more selected from glycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, soybean lecithin and sodium stearate.

8. The production method according to claim 2, wherein the acid is one or more selected from acetic acid, lactic acid, citric acid, adipic acid, hydrochloric acid and phosphoric acid.

9. The production method according to claim 1, wherein the cycrodextrin is cyclodextrin.

10. A production method of a melinjo extract, comprising an extraction step of extracting an extract from melinjo fruit by using an extraction solvent which is a mixed solvent obtained by blending at least one of an emulsifier, a cycrodextrin and an acid into water and/or an organic solvent, wherein the acid is one or more selected from acetic acid, lactic acid, citric acid, adipic acid, hydrochloric acid, and phosphoric acid.