Methods of preparing inhibitors of influenza viruses replication
First Claim
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1. A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula:
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Abstract
A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof:
comprises: (a) reacting Compound (X):
or a pharmaceutically acceptable salt thereof with Compound (Y):
in the presence of a palladium catalyst and a carbonate or phosphate base to form compound (Z):
or a pharmaceutically acceptable salt thereof; and (b) deprotecting the Ts group of Compound (Z) to form Compound (1) or a pharmaceutically acceptable salt thereof.
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10 Claims
- 1. A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula:
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