Non-canonical insulins and their uses
First Claim
1. An insulin derivative, comprising a cyclic amino acid at position B28, wherein the cyclic amino acid is (2S, 4S)-4-hydroxy-L-proline, (2S, 4S)-4-fluoro-L-proline, (2S)-piperidine-2-carboxylic acid, (2S)-4,4-difluoro-L-proline, or (4R)-1,3-thiazolidine-4-carboxylic acid.
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Abstract
In some aspects, the invention relates to an insulin derivative, comprising a cyclic amino acid at position B28 or B29, wherein the cyclic amino acid is not L-proline. In some aspects, the invention relates to a method of making said insulin derivative. In some aspects, the invention relates to a pharmaceutical composition comprising said insulin derivative. In some aspects the invention relates to a method of treating a disease or condition in a subject comprising administering to the subject a composition comprising said insulin derivative.
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Citations
20 Claims
- 1. An insulin derivative, comprising a cyclic amino acid at position B28, wherein the cyclic amino acid is (2S, 4S)-4-hydroxy-L-proline, (2S, 4S)-4-fluoro-L-proline, (2S)-piperidine-2-carboxylic acid, (2S)-4,4-difluoro-L-proline, or (4R)-1,3-thiazolidine-4-carboxylic acid.
Specification