Lens solution, contact lens, and production method therefor

• US 10,640,732 B2
• Filed: 02/06/2015
• Issued: 05/05/2020
• Est. Priority Date: 02/06/2014
• Status: Active Grant

• Current Assignee: JSR Corporation, JSR Life Sciences Corporation
• Original Assignee: JSR Corporation
• Inventors: Iso, Kazuhiro, Hyugaji, Satoshi
• Primary Examiner(s): Mruk, Brian P
• Application Number:
  US15/116,437
• Publication Number:
  US 20170058237A1
• Time in Patent Office: 1,915 Days
• CPC Class Codes: A61F 2/16 Intraocular lenses
• CPC Class Codes: C11D 3/0078 Compositions for cleaning contact lenses, spectacles or lenses
• CPC Class Codes: C11D 3/3765 in liquid compositions
• CPC Class Codes: C11D 3/3773 in liquid compositions
• CPC Class Codes: C11D 3/378 (Co)polymerised monomers containing sulfur, e.g. sulfonate
• CPC Class Codes: C11D 3/3784 (Co)polymerised monomers containing phosphorus
• CPC Class Codes: G02B 1/043 Contact lenses
• CPC Class Codes: G02C 2202/16 Laminated or compound lenses
• CPC Class Codes: G02C 7/04 Contact lenses for the eyes disinfection or sterilisation of contact lenses A61L12/00
• CPC Class Codes: G02C 7/049 Contact lenses having special fitting or structural features achieved by special materials or material structures

Abstract

Provided is a lens solution which has excellent lipid detergency, exhibits high hydrophilization performance, and exhibits an excellent lipid adhesion preventive effect and an excellent lubricity-imparting effect when the solution is used to coat a lens. Disclosed is a lens solution containing a polymer having 2.5% to 95% by mass of the following repeating unit (A) and 2.5% to 95% by mass of the following repeating unit (B):

• • (A) a hydrophilic repeating unit; and
  • (B) a repeating unit having a polyoxyalkylene group in a side chain and having the end of the side chain formed from an alkyl group having 5 to 30 carbon atoms, an alkanoyl group having 5 to 30 carbon atoms, or an aryl group.

Claims

1. A solution comprising a polymer having 2.5% to 95% by mass of the following repeating unit (A) and 2.5% to 95% by mass of the following repeating unit (B):

(A) a hydrophilic repeating unit; and

(B) a repeating unit having a polyoxyalkylene group in a side chain and having the end of the side chain formed from an alkyl group having 5 to 30 carbon atoms, an alkanoyl group having 5 to 30 carbon atoms, or an aryl group,

wherein the repeating unit (A) comprises a repeating unit (A-3) represented by the following formula (4) and a betaine-containing repeating unit (A-6) represented by the following formula (7);

2. The solution according to claim 1, wherein the repeating unit (B) is represented by the following formula (10):

3. The solution according to claim 1, wherein the polymer further comprises 40% by mass or less of a repeating unit (C), the repeating unit (C) being one or more selected from the group consisting of a repeating unit represented by the following formula (11), and a repeating unit having a group represented by the following formula (12) at the end of a side chain:

4. The solution according to claim 1, wherein the polymer is a water-soluble polymer.

5. The solution according to claim 4, formulated for cleaning or storage of a contact lens.

6. The solution according to claim 5, comprising 0.001% to 10% by mass of the polymer.

7. The solution according to claim 1 formulated, for coating a contact lens.

8. A method for producing a surface-modified contact lens, comprising bringing the solution according to claim 1 into contact with at least a part of a contact lens surface.

10. The solution according to claim 1, wherein a content of the repeating unit (A) is 30 to 95% by mass in the polymer, and a content of the repeating unit B is 2.5% to 70% by mass in the polymer.

11. The solution according to claim 1, wherein a content of the repeating unit (A) is 40 to 95% by mass in the polymer, and a content of the repeating unit B is 2.5 to 60% by mass in the polymer,

and wherein

the repeating unit (A) is dimethylacrylamide/N-methacryloyloxyethyl-N,N-dimethylammonium-α

-N-methylcarboxybetaine, and

the repeating unit (B) is lauroxypolyethylene glycol monomethacrylate.

9. A contact lens comprising, in at least a part of the surface, a polymer containing 2.5% to 95% by mass of the following repeating unit (A) and 2.5% to 95% by mass of the following repeating unit (B):

(A) a hydrophilic repeating unit; and

(B) a repeating unit having a polyoxyalkylene group in a side chain and having the end of the side chain formed from an alkyl group having 5 to 30 carbon atoms or an alkanoyl group having 5 to 30 carbon atoms,

wherein the repeating unit (A) comprises a repeating unit (A-3) represented by the following formula (4) and a betaine-containing repeating unit (A-6) represented by the following formula (7);

12. A polymer comprising 2.5% to 95% by mass of the following repeating unit (A) and 2.5% to 95% by mass of the following repeating unit (B):

(A) a hydrophilic repeating unit; and

(B) a repeating unit having a polyoxyalkylene group in a side chain and having the end of the side chain formed from an alkyl group having 5 to 30 carbon atoms, an alkanoyl group having 5 to 30 carbon atoms, or an aryl group, wherein

the repeating unit (A) comprises a repeating unit (A-3) represented by the following formula (4) and a betaine-containing repeating unit (A-6) represented by the following formula (7);

13. The polymer according to claim 12, wherein R¹³ and R¹⁴ in formula (4) each independently represent a hydrogen atom or an alkyl group having 1 to 6 carbon atoms.

14. The polymer according to claim 12, wherein R²⁰ and R²¹ in formula (7) each independently represent a divalent hydrocarbon group having 1 to 10 carbon atoms.

15. The polymer according to claim 12, wherein the repeating unit (B) is represented by the following formula (10):

16. The polymer according to claim 15, wherein R³³ in formula (10) represents an alkyl group having 5 to 30 carbon atoms.

17. The polymer according to claim 15, wherein R³⁵ in formula (10) represents **—

(C═

O)—

O⁻

, **—

(C═

O)—

NR³⁶—

, **—

NR³⁶—

(C═

O)—

or a phenylene group.

18. The polymer according to claim 12, further comprising one or more of a repeating unit (C) selected from the group consisting of a repeating unit (C-1) represented by the following formula (11), and a repeating unit (C-2) having a group represented by the following formula (12) at the end of a side chain:

19. The polymer according to claim 18, wherein the repeating unit (C) is the repeating unit (C-1).

20. The polymer according to claim 18, wherein a content of the repeating unit (C) is 0.1% by mass to 40% by mass.