Engineered enzymes
First Claim
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1. An engineered nucleic acid-guided nuclease with an altered fidelity relative to the nucleic acid-guided nuclease having the sequence of SEQ ID No. 1, wherein the engineered nucleic acid-guided nuclease has a sequence comprising any of SEQ ID Nos. 4-7.
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Abstract
The present disclosure provides engineered RNA-guided enzymes for editing live cells.
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14 Claims
- 1. An engineered nucleic acid-guided nuclease with an altered fidelity relative to the nucleic acid-guided nuclease having the sequence of SEQ ID No. 1, wherein the engineered nucleic acid-guided nuclease has a sequence comprising any of SEQ ID Nos. 4-7.
Specification