Yeast strains with reduced fatty alcohol oxidase activity and method for the production of omega-hydroxy fatty acids and dicarboxylic acids
First Claim
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1. A genetically engineered Yarrowia lipolytica cell, comprising:
- a. a disrupted fatty alcohol oxidase encoding FAO1 YALI0B14014g gene; and
b. at least one disrupted acyl-CoA oxidase encoding gene selected from the group consisting of;
POX1, POX2, POX3, POX4, POX5, and POX6,wherein the engineered Yarrowia lipolytica cell has reduced fatty alcohol oxidase activity relative to a wild type Yarrowia lipolytica cell.
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Abstract
The invention relates to various new yeast strains of the type Yarrowia lipolytica as well as relevant methods for the biocatalytic preparation of ω-hydroxy fatty acids or dicarboxylic acids with the aid of these strains, whereby the formation of ω-hydroxy fatty acids or dicarboxylic acids is advantageously increased.
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Citations
21 Claims
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1. A genetically engineered Yarrowia lipolytica cell, comprising:
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a. a disrupted fatty alcohol oxidase encoding FAO1 YALI0B14014g gene; and b. at least one disrupted acyl-CoA oxidase encoding gene selected from the group consisting of;
POX1, POX2, POX3, POX4, POX5, and POX6,wherein the engineered Yarrowia lipolytica cell has reduced fatty alcohol oxidase activity relative to a wild type Yarrowia lipolytica cell. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A genetically engineered Yarrowia lipolytica cell, comprising:
- a disrupted fatty alcohol oxidase encoding FAO1 YALI0B14014g gene.
- View Dependent Claims (21)
Specification