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Multiple hybrid immunoassay

  • US 10,641,767 B2
  • Filed: 05/09/2018
  • Issued: 05/05/2020
  • Est. Priority Date: 07/29/2002
  • Status: Expired due to Fees
First Claim
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1. A cartridge for sensing at least one analyte in a sample, said cartridge comprising:

  • a housing;

    at least one sensor located within the housing;

    a cavity within the housing including a sealed deformable pouch for retaining an aqueous reagent out of contact with the sensor;

    an aqueous reagent conduit for connecting the cavity to the sensor;

    aqueous reagent displacer under control of a reading apparatus for displacing the aqueous reagent from the cavity through the aqueous reagent conduit to the sensor;

    sample holding chamber within the housing, for retaining the sample out of contact with the sensor, prior to sensing;

    sample collector within the housing including an orifice for drawing the sample into the sample holding chamber;

    a sample conduit connecting the sample holding chamber with the sensor;

    sample displacer for forcibly displacing the sample from said sample holding chamber through the sample conduit and into contact with the sensor to permit sensing; and

    an immunoassay composition for detecting said analyte comprising at least three different antibodies, the at least three different antibodies being capable of binding to at least three different epitopes on said analyte, in which at least two of the at least three different antibodies are capable of binding to at least two different epitopes on a subform of said analyte, and in which at least one of the at least three different epitopes on said analyte is unavailable for binding on the subform.

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