Ultrasound diagnosis method and apparatus for analyzing contrast enhanced ultrasound image

• US 10,646,203 B2
• Filed: 03/28/2016
• Issued: 05/12/2020
• Est. Priority Date: 10/08/2015
• Status: Active Grant

• Current Assignee: Samsung Medison Company Limited (Samsung Electronics Co. Ltd.)
• Original Assignee: Samsung Medison Company Limited (Samsung Electronics Co. Ltd.)
• Inventors: Ryoo, Ho-jin, Kim, Jong-sik, Lee, Jin-yong
• Primary Examiner(s): Fernandez, Katherine L
• Assistant Examiner(s): Yang, Yi-Shan
• Application Number:
  US15/082,174
• Publication Number:
  US 20170100101A1
• Time in Patent Office: 1,506 Days
• Field of Search: None
• CPC Class Codes: A61B 8/085 for locating body or organic structures, e.g. tumours, calculi, blood vessels, nodules
• CPC Class Codes: A61B 8/14 Echo-tomography
• CPC Class Codes: A61B 8/465 adapted to display user selection data, e.g. icons or menus
• CPC Class Codes: A61B 8/469 for selection of a region of interest
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039
• CPC Class Codes: A61B 8/5207 involving processing of raw data to produce diagnostic data, e.g. for generating an image reconstruction G06T11/00
• CPC Class Codes: A61B 8/5215 involving processing of medical diagnostic data
• CPC Class Codes: A61B 8/5276 due to motion

Abstract

Provided are an ultrasound diagnosis apparatus and method for analyzing a contrast enhanced ultrasound image. The ultrasound diagnosis apparatus and method determine, by analysis, causes of defects in a frame of an ultrasound image based on a time intensity curve and allow visual display of the defective frame based on the determined causes. Furthermore, the ultrasound diagnosis method and apparatus may provide a user interface for quick access to causes of defects in a frame of the ultrasound image and to a position of the defective frame.

Claims

1. An ultrasound diagnosis apparatus for analyzing a contrast enhanced ultrasound image with respect to an object to which an ultrasound contrast medium has been administered, the contrast enhanced ultrasound image being obtained by transmitting ultrasound waves to the object and receiving echo signals reflected from the object, the ultrasound diagnosis apparatus comprising:

a processor configured to;

acquire a time intensity curve representing an intensity value of a region of interest (ROI) of ultrasound image frames and a fitting curve representing a tendency of the time intensity curve according to a preset mathematical model,

calculate a difference between the time intensity curve and the fitting curve for each of the ultrasound image frames, and

determine a defective frame related to a movement or a change in size of the object in the ROI from among the ultrasound image frames when the calculated difference exceeds a threshold value for each of the ultrasound image frames; and

a user input interface configured to display a graphical user interface (GUI) related to the defective frame.

2. The ultrasound diagnosis apparatus of claim 1, wherein the processor is further configured to determine the defective frame by analyzing at least one of a simple movement that is a temporary deviation of an anatomical structure in the object away from the ROI, a periodic movement that is a periodic deviation of the anatomical structure in the object away from the ROI, and the change in size of the object in the ROI.

3. The ultrasound diagnosis apparatus of claim 1, wherein the processor is further configured to recognize a state in which an ultrasound probe is not in contact with the object.

4. The ultrasound diagnosis apparatus of claim 1, wherein the processor is further configured to analyze a type of the movement of the object and the change in size of the object based on the difference between the time intensity curve and the fitting curve, and the user input interface displays, based on a result of the analyzing, the GUI corresponding to each of the type of movement of the object, the change in size of the object, and a state of non-contact between an ultrasound probe and the object.

5. The ultrasound diagnosis apparatus of claim 1, further comprising a display configured to display the defective frame.

6. The ultrasound diagnosis apparatus of claim 1, wherein the processor is further configured to determine that an anatomical structure in the object has periodically deviated away from the ROI when the calculated difference periodically exceeds the threshold value.

7. The ultrasound diagnosis apparatus of claim 1, wherein the threshold value is determined based on an average of differences between the time intensity curve and the fitting curve for each of the ultrasound image frames and a standard deviation of the differences.

8. The ultrasound diagnosis apparatus of claim 1, further comprising a display configured to display the time intensity curve, the fitting curve, a difference curve representing the difference between the time intensity curve and the fitting curve for each of the ultrasound image frames, and a threshold curve representing the threshold value for each of the ultrasound image frames.

9. The ultrasound diagnosis apparatus of claim 1, wherein the processor is further configured to:

set an additional ROI, which is larger than and includes the ROI, in each of the ultrasound image frames,

acquire a time intensity curve for each of the ultrasound image frames within the additional ROI, and

analyze a change in intensity values of each of the ultrasound image frames within the additional ROI based on the acquired time intensity curve for the additional ROI.

10. The ultrasound diagnosis apparatus of claim 9, wherein the processor is further configured to analyze movement of the object included in the additional ROI and a change in size of the object based on the result of the analyzing the change in intensity values of each of the ultrasound image frames within the additional ROI.

11. A method of analyzing an ultrasound image with respect to an object to which an ultrasound contrast medium has been administered, the ultrasound image being obtained by transmitting ultrasound waves to the object and receiving echo signals reflected from the object, the method comprising:

acquiring a time intensity curve representing an average of intensity values of a region of interest (ROI) of ultrasound image frames and a fitting curve representing a tendency of the time intensity curve according to a preset mathematical model;

calculating a difference between the acquired time intensity curve and the fitting curve for each of the ultrasound image frames;

determining a defective frame related to a movement or a change in size of the object in the ROI from among the ultrasound image frames when the calculated difference exceeds a threshold value for each of the ultrasound image frames; and

displaying a graphical user interface (GUI) related to the defective frame.

12. The method of claim 11, further comprising:

receiving, via a user interface, a user input for selecting at least one of the type of movement of the object and the change in size of the object; and

displaying, based on the user input, the defective frame.

13. The method of claim 11, wherein the determining the defective frame comprises determining the defective frame by analyzing at least one of a simple movement that is a temporary deviation of an anatomical structure in the object away from the ROI, a periodic movement that is a periodic deviation of the anatomical structure in the object away from the ROI, and the change in size of the object in the ROI.

14. The method of claim 11, further comprising:

recognizing a state in which an ultrasound probe is not in contact with the object.

15. The method of claim 14, wherein the recognizing of the state in which the ultrasound probe is not in contact with the object comprises:

determining at least one ultrasound image frame from among the ultrasound image frames at which the time intensity curve for the ultrasound image frame has a value of 0; and

determining the at least one ultrasound image frame as the defective frame captured when the ultrasound probe is not in contact with the object.

16. The method of claim 11, wherein the threshold value is determined based on an average of differences between the time intensity curve and the fitting curve for each of the ultrasound image frames and a standard deviation of the differences.

17. The method of claim 11, further comprising:

setting an additional ROI, which is larger than and includes the ROI, in each of the ultrasound image frames;

acquiring a time intensity curve for each of the ultrasound image frames included in the additional ROI; and

analyzing a change in intensity values of each of the ultrasound image frames included in the additional ROI based on the acquired time intensity curve for the additional ROI.

18. The method of claim 17, further comprising:

analyzing the movement of the object and the change in size of the object based on a result of the analyzing of the change in intensity values of each of the ultrasound image frames included in the additional ROI.

19. The method of claim 17, further comprising:

analyzing, based on the acquired time intensity curve for the additional ROI, whether the intensity values of each of the ultrasound image frames included in the additional ROI periodically change.

20. The method of claim 11, wherein the displaying of the user interface comprises displaying a highlight associated with the defective frame on the time intensity curve at a position where an intensity is associated with the defective frame to distinguish the defective frame from other ultrasound image frames.

21. The method of claim 11, further comprising displaying an ultrasound image from among the ultrasound image frames selected based on a user input.

22. A non-transitory computer-readable recording medium having recorded thereon a program for executing the method of claim 11 on a computer.