Formulations of intraarticular pharmaceutical agents and methods for preparing and using the same
First Claim
1. A method for lubricating a joint of a mammal comprising administered into a cavity of the joint an effective amount of a composition comprising between 0.01% and 6% (weight/volume) polyethylene glycol (PEG) 600K-10M, between 0.1% and 5% (weight/volume) PEG 100K-600K, and 0.1% to 10% (weight/volume) PEG 260-100K, wherein the composition comprises at least 1.6% (weight/volume) polyethylene glycol (PEG), wherein the composition is a liquid at the temperature of the joint and the oncotic pressure of the composition is not greater than the serum oncotic pressure of the mammal.
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Abstract
Provided herein are compositions and methods for preparing intraarticular formulations comprising biocompatible pharmaceutical agents and use thereof in the treatment of diseases, such as degenerative bone diseases, including osteoarthritis of the knee, hip, or other joints, and similar chronic or acute destructive arthropathies resulting from autoimmune disorders or infectious disease.
28 Citations
17 Claims
- 1. A method for lubricating a joint of a mammal comprising administered into a cavity of the joint an effective amount of a composition comprising between 0.01% and 6% (weight/volume) polyethylene glycol (PEG) 600K-10M, between 0.1% and 5% (weight/volume) PEG 100K-600K, and 0.1% to 10% (weight/volume) PEG 260-100K, wherein the composition comprises at least 1.6% (weight/volume) polyethylene glycol (PEG), wherein the composition is a liquid at the temperature of the joint and the oncotic pressure of the composition is not greater than the serum oncotic pressure of the mammal.
Specification