Activated disinfectant hydrogen peroxide compositions

• US 10,646,607 B2
• Filed: 09/17/2015
• Issued: 05/12/2020
• Est. Priority Date: 09/17/2014
• Status: Active Grant

• Current Assignee: Arxada LLC
• Original Assignee: Lonza Incorporated (Lonza Group AG)
• Inventors: Lei, Deqing, Sweeny, Philip Gerdon
• Primary Examiner(s): Rosenthal, Andrew S
• Application Number:
  US14/857,403
• Publication Number:
  US 20160074549A1
• Time in Patent Office: 1,699 Days
• CPC Class Codes: A01N 25/30 characterised by the surfactants
• CPC Class Codes: A01N 41/04 Sulfonic acids; Derivatives thereof
• CPC Class Codes: A01N 59/00 Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
• CPC Class Codes: A61L 2/186 Peroxide solutions

Abstract

Activated hydrogen peroxide disinfecting compositions are provided especially for low-foaming applications. A concentrate for dilution by an end-user is provided, which includes a hydrogen peroxide source, a non-surfactant organic sulfonic acid or salt thereof, a non-ionic surfactant, and an optional organic acid. Also provided is a ready-to-use hydrogen peroxide, disinfectant solution including a biocidal amount of hydrogen peroxide, a non-surfactant organic sulfonic acid or salt thereof, a non-ionic surfactant, water as solvent and an optional organic acid. An end-user can disinfect a surface of microorganisms by contacting the surface with the disinfecting composition for an amount of time effective to kill a majority of the microbes located on the surface.

Claims

1. A hydrogen peroxide, disinfectant concentrate comprising:

a hydrogen peroxide source providing a hydrogen peroxide concentration from 2 to 8 weight percent of the total concentrate,

a non-surfactant organic sulfonic acid or salt thereof from 2 to 15 weight percent of the total concentrate, and

a non-ionic surfactant from 0.5 to 8 weight percent of the total concentrate, and

an optional acid other than the non-surfactant organic sulfonic acid from 0.2 to 10 weight percent of the total concentrate,

wherein the concentrate is free of an anionic surfactant,

wherein the concentrate dissolved in water provides a ready-to-use, disinfectant solution with a pH from 0.5 to 4.0,

wherein the concentrate dissolved in water provides the ready-to-use, disinfectant solution with 0.05 to 2 weight percent hydrogen peroxide,

wherein the hydrogen peroxide source, the non-surfactant organic sulfonic acid or salt thereof, the non-ionic surfactant, and the optional acid provide the ready-to-use, disinfectant solution with a Log₁₀ microbial reduction ≥

4 within a 3-minute contact time against Staphylococcus aureus (Sa),

wherein the non-surfactant organic sulfonic acid or salt thereof is selected from the group consisting of methane sulfonic acid, benzene sulfonic acid, toluene sulfonic acid, xylene sulfonic acid, ethylbenzene sulfonic acid or mixtures thereof, and

wherein the optional acid is glutaric acid, citric acid, phosphoric acid, etidronic acid, or mixtures thereof.

2. The hydrogen peroxide, disinfectant concentrate of claim 1, wherein the non-surfactant organic sulfonic acid is methane sulfonic acid.

3. The hydrogen peroxide, disinfectant concentrate of claim 1, wherein the non-surfactant organic sulfonic acid is benzene sulfonic acid.

4. The hydrogen peroxide, disinfectant concentrate of claim 1, wherein the non-surfactant organic sulfonic acid is toluene sulfonic acid, xylene sulfonic acid, ethylbenzene sulfonic acid or mixtures thereof.

5. The hydrogen peroxide, disinfectant concentrate of claim 1, wherein the salt is an alkali metal salt, an alkaline earth metal salt or an ammonium salt.

6. The hydrogen peroxide, disinfectant concentrate of claim 1, wherein the optional acid is glutaric acid or citric acid.

7. The hydrogen peroxide, disinfectant concentrate of claim 1, wherein the optional acid is etidronic acid.

8. The hydrogen peroxide, disinfectant concentrate of claim 1, wherein the optional acid is phosphoric acid.

9. The hydrogen peroxide, disinfectant concentrate of claim 1, wherein the nonionic surfactant is a C₈ to C₁₄ alkylated polyethylene glycol, C₈ to C₁₄ alkylated polypropylene glycol, polyoxyethylene glycol alkylphenol ethers and glucoside alkyl ethers, or mixtures thereof.

10. The hydrogen peroxide, disinfectant concentrate of claim 1, further comprising of a hydrogen peroxide stabilizer and a metal corrosion inhibitor each in a concentration of 0.05 to 0.5 weight percent of the total concentrate.

11. The hydrogen peroxide, disinfectant concentrate of claim 1, wherein the concentrate is a solid formulation in the form of a powder or tablet.

12. The hydrogen peroxide, disinfectant concentrate of claim 1, wherein the hydrogen peroxide source is hydrogen peroxide solution, sodium percarbonate, potassium percarbonate, sodium and potassium perborate, hydrogen peroxide urea, hydrated forms thereof, or mixtures thereof.

13. A ready-to-use hydrogen peroxide, disinfectant solution comprising:

a biocidal amount of hydrogen peroxide from 0.05 to 2 weight percent of the total solution,

a non-surfactant organic sulfonic acid or salt thereof from 0.05 to 5.0 weight percent of the total solution,

a non-ionic surfactant from 0.05 to 3.0 weight percent of the total solution,

an optional acid other than the non-surfactant organic sulfonic acid from 0.05 to 6.0 weight percent of the total solution, and

water,

wherein the ready-to-use hydrogen peroxide, disinfectant solution is free of an anionic surfactant,

wherein the ready-to-use hydrogen peroxide, disinfectant solution has a pH from 0.5 to 4.0, and

wherein the hydrogen peroxide source, the non-surfactant organic sulfonic acid or salt thereof, the non-ionic surfactant, and the optional acid provide the ready-to-use hydrogen peroxide, disinfectant solution with a Log₁₀ microbial reduction ≥

4 within a 3-minute contact time against Staphylococcus aureus (Sa),

wherein the non-surfactant organic sulfonic acid or salt thereof is selected from the group consisting of methane sulfonic acid, benzene sulfonic acid, toluene sulfonic acid, xylene sulfonic acid, ethylbenzene sulfonic acid or mixtures thereof, and

wherein the optional acid is glutaric acid, citric acid, phosphoric acid, etidronic acid, or mixtures thereof.

14. The ready-to-use hydrogen peroxide, disinfectant solution of claim 13, wherein the optional acid is glutaric acid or citric acid.

15. The ready-to-use hydrogen peroxide, disinfectant solution of claim 13, wherein the optional acid is etidronic acid.

16. The ready-to-use hydrogen peroxide, disinfectant solution of claim 13, wherein the optional acid is phosphoric acid.

17. The ready-to-use hydrogen peroxide, disinfectant solution of claim 13, wherein the solution has a pH of from 1 to 3.

18. The ready-to-use hydrogen peroxide, disinfectant solution of claim 13, wherein the non-surfactant organic sulfonic acid is methane sulfonic acid.

19. The ready-to-use hydrogen peroxide, disinfectant solution of claim 13, wherein the non-surfactant organic sulfonic acid is benzene sulfonic acid.

20. The ready-to-use hydrogen peroxide, disinfectant solution of claim 13, wherein the non-surfactant organic sulfonic acid is toluene sulfonic acid, xylene sulfonic acid, ethylbenzene sulfonic acid or mixtures thereof.

21. The ready-to-use hydrogen peroxide, disinfectant solution of claim 13, wherein the salt is an alkali metal salt, an alkaline earth metal salt or an ammonium salt.

22. The hydrogen peroxide disinfectant concentrate of claim 1, further comprising of biocidal quaternary ammonium salt in an amount from 0.1 to 10 weight percent of the total concentrate.

23. The ready-to-use hydrogen peroxide, disinfectant solution of claim 13, comprising of biocidal quaternary ammonium salt in an amount from 0.1 to 5 weight percent of the solution.

24. A method of disinfecting a surface of microorganisms, the method comprising:

contacting said surface with a disinfecting composition comprising of

(i) a biocidal amount of hydrogen peroxide from 0.05 to 2 weight percent of the disinfecting composition,

(ii) a non-surfactant organic sulfonic acid or salt thereof from 0.05 to 5.0 weight percent of the disinfecting composition,

(iii) a non-ionic surfactant from 0.05 to 3.0 weight percent of the disinfecting composition,

(iv) an optional acid other than the non-surfactant organic sulfonic acid from 0.05 to 6.0 weight percent of the disinfecting composition, and

(v) water,

wherein the disinfecting composition is free of an anionic surfactant,

wherein the disinfecting composition has a pH from 0.5 to 4.0,

wherein the hydrogen peroxide source, the non-surfactant organic sulfonic acid or salt thereof, the non-ionic surfactant, and the optional acid provide the disinfecting composition with a Log₁₀ microbial reduction ≥

4 within a 3-minute contact time against Staphylococcus aureus (Sa),

wherein the non-surfactant organic sulfonic acid or salt thereof is selected from the group consisting of methane sulfonic acid, benzene sulfonic acid, toluene sulfonic acid, xylene sulfonic acid, ethylbenzene sulfonic acid or mixtures thereof, and

wherein the optional acid is glutaric acid, citric acid, phosphoric acid, etidronic acid, or mixtures thereof, and

wherein said surface is contacted for an amount of time effective to kill a majority of the microbes located on the surface.

25. The method of claim 24, wherein the microorganisms are Gram positive bacteria, Gram negative bacteria, viruses, fungi, mildew, mold or combinations thereof.

26. The method of claim 24, wherein the microorganisms are Staphylococcus, Pseudomonas, hepatitis, rotavirus, rhinovirus, tuberculosis or combinations thereof.

27. The method of claim 24, wherein the surface is a floor, a wall, a countertop, an appliance, or a fixture.

28. The hydrogen peroxide, disinfectant concentrate of claim 1, further comprising 0.5 to 5 weight percent of a zwitterionic surfactant.

29. The ready-to-use hydrogen peroxide, disinfectant solution of claim 13, further comprising 0.5 to 5 weight percent of a zwitterionic surfactant.

30. A two-part disinfectant, comprising:

a first container including a non-surfactant organic sulfonic acid or salt thereof, a non-ionic surfactant, and an optional acid other than the non-surfactant organic sulfonic acid; and

a second container including a biocidal amount of hydrogen peroxide from 2 to 8 weight percent of the disinfectant, and water;

wherein the two-part disinfectant is free of an anionic surfactant,

wherein the two-part disinfectant provides a ready-to-use, disinfectant solution with a pH from 0.5 to 4.0;

wherein the two-part disinfectant provides the ready-to-use, disinfectant solution with 0.05 to 2 weight percent of hydrogen peroxide,

wherein the two-part disinfectant provides the ready-to-use, disinfectant solution with 0.05 to 5.0 weight percent of non-surfactant organic sulfonic acid or salt thereof,

wherein the two-part disinfectant provides the ready-to-use, disinfectant solution with 0.05 to 3.0 weight percent of non-ionic surfactant,

wherein the two-part disinfectant provides the ready-to-use, disinfectant solution with 0.05 to 6.0 weight percent of optional acid, and

wherein the hydrogen peroxide source, the non-surfactant organic sulfonic acid or salt thereof, the non-ionic surfactant, and the optional acid of the two-part disinfectant provides the ready-to-use, disinfectant solution with a Log₁₀ microbial reduction ≥

4 within a 3-minute contact time against Staphylococcus aureus (Sa).

31. The two-part disinfectant of claim 30, wherein additional components are included only in the first container.

32. The ready-to-use hydrogen peroxide, disinfectant solution of claim 13, further comprising a water-miscible organic solvent selected from the group consisting of ethanol, propanol, benzyl alcohol, phenoxyethanol, isopropanol, diethylene glycol propyl ether, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, ethylene glycol monoisopropyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monobutyl ether, diethylene glycol monoethyl ether, diethylene glycol mono-n-butyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether, propylene glycol n-butyl ether, tripropylene glycol methyl ether, dipropylene glycol methyl ether, dipropylene glycol butyl ether and combinations thereof.

33. The hydrogen peroxide, disinfectant concentrate of claim 1, further comprising 0.5 to 5 weight percent of an ionic surfactant.

34. The ready-to-use hydrogen peroxide, disinfectant solution of claim 13, further comprising 0.5 to 5 weight percent of an ionic surfactant.

35. The hydrogen peroxide, disinfectant concentrate of claim 1, wherein the concentrate dissolved in water provides the ready-to-use, disinfectant solution with a pH from 1 to 3.

36. The two-part disinfectant of claim 30, wherein the two-part disinfectant provides the ready-to-use, disinfectant solution with a pH from 1 to 3.

37. The hydrogen peroxide, disinfectant concentrate of claim 35, wherein the pH is between 1 and 2.

38. The ready-to-use hydrogen peroxide, disinfectant solution of claim 17, wherein the pH is between 1 and 2.

39. The two-part disinfectant of claim 30, wherein the pH is between 1 and 2.

40. The method of claim 24, wherein the pH of disinfecting composition is from 1 to 3.

41. The method of claim 40, wherein the pH is between 1 and 2.

42. The method of claim 24, wherein the disinfecting composition further comprises 0.5 to 5 weight percent of an ionic surfactant.

43. The two-part disinfectant of claim 30, further comprising 0.5 to 5 weight percent of an ionic surfactant.

44. The method of claim 24, wherein the disinfecting composition further comprises 0.5 to 5 weight percent of a zwitterionic surfactant.

45. The two-part disinfectant of claim 30, further comprising 0.5 to 5 weight percent of a zwitterionic surfactant.

46. The two-part disinfectant of claim 30, wherein the non-surfactant organic sulfonic acid is methane sulfonic acid.

47. The two-part disinfectant of claim 30, wherein the non-surfactant organic sulfonic acid is benzene sulfonic acid.

48. The two-part disinfectant of claim 30, wherein the non-surfactant organic sulfonic acid is toluene sulfonic acid, xylene sulfonic acid, ethylbenzene sulfonic acid or mixtures thereof.

49. The two-part disinfectant of claim 30, wherein the optional acid is glutaric acid or citric acid.

50. The two-part disinfectant of claim 30, wherein the optional acid is etidronic acid.

51. The two-part disinfectant of claim 30, wherein the optional acid is phosphoric acid.

52. The two-part disinfectant of claim 30, further comprising 0.5 to 5 weight percent of a zwitterionic surfactant.

53. The two-part disinfectant of claim 30, further comprising of biocidal quaternary ammonium salt in an amount from 0.1 to 10 weight percent of the total concentrate.

54. The two-part disinfectant of claim 30, wherein the two-part disinfectant provides the ready-to-use, disinfectant solution with pH from 1 to 3.

55. The two-part disinfectant of claim 30, wherein the second container further comprises of a hydrogen peroxide stabilizer in a concentration of 0.05 to 0.5 weight percent of the disinfectant.

56. The method of claim 24, wherein the non-surfactant organic sulfonic acid is methane sulfonic acid.

57. The method of claim 24, wherein the non-surfactant organic sulfonic acid is benzene sulfonic acid.

58. The method of claim 24, wherein the non-surfactant organic sulfonic acid is toluene sulfonic acid, xylene sulfonic acid, ethylbenzene sulfonic acid or mixtures thereof.

59. The method of claim 24, wherein the optional acid is glutaric acid or citric acid.

60. The method of claim 24, wherein the optional acid is etidronic acid.

61. The method of claim 24, wherein the optional acid is phosphoric acid.

62. The method of claim 24, wherein the disinfecting composition further comprises 0.1 to 5 weight percent of a biocidal quaternary ammonium salt.

63. The method of claim 24, wherein the disinfecting composition further comprises a hydrogen peroxide stabilizer in a concentration of 0.05 to 0.5 weight percent of the disinfecting composition.