Transdermal electrical stimulation at the neck

• US 10,646,708 B2
• Filed: 04/30/2018
• Issued: 05/12/2020
• Est. Priority Date: 05/20/2016
• Status: Active Grant

• Current Assignee: Thync Global, Inc.
• Original Assignee: Thync Global, Inc.
• Inventors: Goldwasser, Isy, Jeffery, Douglas, Pal, Sumon K., Law, Wing
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): Piateski, Erin M
• Application Number:
  US15/967,576
• Publication Number:
  US 20180272118A1
• Time in Patent Office: 743 Days
• CPC Class Codes: A61N 1/0456 Specially adapted for transcutaneous electrical nerve stimulation [TENS]
• CPC Class Codes: A61N 1/048 Electrodes characterised by a specific connection between lead and electrode
• CPC Class Codes: A61N 1/0492 Patch electrodes A61N1/0412, A61N1/0428 take precedence
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36017 with leads or electrodes penetrating the skin
• CPC Class Codes: A61N 1/36021 for treatment of pain
• CPC Class Codes: A61N 1/36025 for treating a mental or cerebral condition
• CPC Class Codes: A61N 1/36034 specified by the stimulation parameters

Abstract

Described herein are methods and apparatuses for the application of transdermal electrical stimulation (TES). The apparatuses described herein include neck-worn devices having electrodes (or configured to connect to electrodes, including automatically self-connecting to electrodes) adapted to couple to the midline of the back of user'"'"'s neck. A neck-worn controller may be configured as a cord, band, wire, torc, necklace, loop, strap, or the like, and may be rigid or semi-rigid and may be worn at least partially around the subject'"'"'s neck. The controller may controllably apply one or more waveforms to the electrodes of the electrode pad (e.g., patch) to deliver TES adapted to treat a disorder (e.g., psoriasis) and/or to induce or enhance a relaxed cognitive state.

Claims

1. A method of treating psoriasis by applying transdermal electrical stimulation (TES) to the back of a user'"'"'s neck, the method comprising:

placing an anode and a cathode along a midline of a back of the user'"'"'s neck between a region over the user'"'"'s C3 cervical region and the user'"'"'s T2 thoracic region, wherein the anode is separated from the cathode by between 0.8 and 2.2 inches;

applying electrical energy between the anode and the cathode to deliver TES, wherein the electrical energy is applied for 2 minutes or greater.

2. The method of claim 1, wherein placing comprises adhesively attaching the anode and the cathode.

3. The method of claim 1, wherein placing comprises placing the anode and cathode on a patient suffering from psoriasis.

4. The method of claim 1, wherein placing comprises placing the anode and the cathode so that the anode is separated from the cathode by between 0.8 inches and 2.0 inches, and wherein the anode and the cathode are arranged along the midline of the user'"'"'s body so that the anode is over the user'"'"'s C4-C7 region and the cathode is over the user'"'"'s C7-T2 region.

5. The method of claim 1, wherein placing comprises adhesively attaching an electrode pad comprising the anode and the cathode to the back of a user'"'"'s neck so that the anode and the cathode are arranged along the midline of the user'"'"'s neck.

6. The method of claim 1, wherein placing the anode comprises placing a neck-worn TES controller around the neck of the user wherein the TES controller is configured to apply electrical energy between the anode and the cathode.

7. The method of claim 1, wherein applying electrical energy comprises applying TES by delivering electrical energy between the anode and the cathode, wherein the electrical energy comprises a carrier wave having a frequency that is greater than 250 Hz that is amplitude modulated at a frequency that is ten percent or less of the frequency of the carrier wave, further wherein the amplitude modulation is varied at least once every 40 seconds.

8. The method of claim 7, wherein the amplitude modulation is varied by varying the shape of an envelope of the amplitude modulation.

9. The method of claim 7, wherein the amplitude modulation is varied by varying one or both of a symmetry ratio and a flat ratio of the amplitude modulation.

10. The method of claim 1, wherein a surface area of the anode is greater than 1.25 times the surface area of the cathode.

11. The method of claim 1, wherein placing comprises attaching a wearable TES controller to the anode and the cathode.

12. A method of treating psoriasis by applying transdermal electrical stimulation (TES) to the back of a user'"'"'s neck, the method comprising:

placing an anode and a cathode to a back of the user'"'"'s neck along a midline of a long axis of the user'"'"'s body extending anterior to posterior, wherein the anode is positioned over the user'"'"'s C3-C7 region and the cathode is positioned over the user'"'"'s C7-T2 region, wherein the first and the cathode form part of an electrode pad, and wherein the anode is separated from the cathode by between 0.8 and 2.0 inches;

applying TES by delivering electrical energy between the anode and the cathode, wherein the electrical energy comprises a carrier wave having a frequency that is greater than 250 Hz that is amplitude modulated at a frequency that is ten percent or less the frequency of the carrier wave, wherein the electrical energy is applied for 2 minutes or greater.

13. The method of claim 12, wherein placing comprises placing a TES controller around the user'"'"'s neck or shoulders wherein the TES controller is configured to apply electrical energy between the anode and the cathode.

14. The method of claim 12, wherein placing comprises attaching a wearable TES controller to the anode and the cathode.

15. The method of claim 12, wherein applying TES by delivering electrical energy comprises applying the energy at a rise time of between 1 and 20 microseconds.

16. The method of claim 15, wherein the rise-time is varied between 1 and 20 microseconds.

17. The method of claim 12, wherein applying TES comprises applying the carrier wave with a rise time of between 1 and 20 microseconds.

18. The method of claim 17, wherein the rise-time is varied between 1 and 20 microseconds.

19. The method of claim 12, wherein a surface area of the anode is greater than 1.25 times the surface area of the cathode.

20. The method of claim 12, wherein placing comprises placing the anode and cathode on a patient suffering from psoriasis.