Electrospun PTFE coated stent and method of use

• US 10,653,512 B2
• Filed: 01/10/2014
• Issued: 05/19/2020
• Est. Priority Date: 01/28/2011
• Status: Active Grant

• Current Assignee: Merit Medical Systems, Inc.
• Original Assignee: Merit Medical Systems, Inc.
• Inventors: Eller, Zeke, Hall, John William, Kellar, Robert S., Simmons, Rachel Lynn, Radford, Robert J., Dolmatch, Bart
• Primary Examiner(s): Mathew, Seema
• Application Number:
  US14/152,590
• Publication Number:
  US 20140249619A1
• Time in Patent Office: 2,321 Days
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2/88 the wire-like elements formed as helical or spiral coils forming a net-like or mesh-like structure A61F2/90
• CPC Class Codes: A61F 2/89 the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/072 Encapsulated stents, e.g. wire or whole stent embedded in lining
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/146 Porous materials, e.g. foams or sponges
• CPC Class Codes: B32B 27/322 comprising halogenated polyolefins, e.g. PTFE
• CPC Class Codes: C08L 27/18 Homopolymers or copolymers or tetrafluoroethene
• CPC Class Codes: C08L 71/02 Polyalkylene oxides
• CPC Class Codes: D01D 5/0007 Electro-spinning non-woven fabrics produced by electro-spinning D04H1/728
• CPC Class Codes: D01D 5/003 the material being a polymer solution or dispersion D01D5/0053 takes precedence
• CPC Class Codes: D01D 5/0038 the fibre formed by solvent evaporation, i.e. dry electro-spinning
• CPC Class Codes: D01D 5/0046 the fibre formed by coagulation, i.e. wet electro-spinning
• CPC Class Codes: D01D 5/0084 Coating by electro-spinning, i.e. the electro-spun fibres are not removed from the collecting device but remain integral with it, e.g. coating of prostheses

Abstract

A stent or other prosthesis may be formed by coating a single continuous wire scaffold with a polymer coating. The polymer coating may consist of layers of electrospun polytetrafluoroethylene (PTFE). Electrospun PTFE of certain porosities may permit endothelial cell growth within the prosthesis.

Claims

1. A stent, comprising:

a first layer of electrospun polytetrafluoroethylene (PTFE) fibers,

a second layer of electrospun PTFE fibers, wherein the first and second layers have different porosities,

a tie layer disposed between the first and second layers of electrospun PTFE fibers, wherein the tie layer is a non-porous fluorinated ethylene propylene (FEP) film that is impermeable to tissue ingrowth, wherein the film continuously extends to cover the first layer from a first layer proximal end to a first layer distal end; and

a scaffolding structure configured to resist radial compression when disposed in a lumen of a patient;

wherein the scaffolding structure comprises two longitudinal portions of different compressibilities.

2. The stent of claim 1, wherein the scaffolding structure comprises a metal structure.

3. The stent of claim 2, wherein the scaffolding structure comprises a wire.

4. The stent of claim 1, wherein the scaffolding structure comprises a polymeric structure.

5. The stent of claim 1, wherein the scaffolding structure comprises a midbody portion and wherein the midbody portion of the stent is configured to hold open diseased tissue.

6. The stent of claim 5, wherein the midbody portion is relatively less compressible than a first and a second end of the scaffolding structure.

7. The stent of claim 1, wherein the scaffolding structure defines two end portions configured to reduce trauma to healthy tissue at the ends of the stent.