Fluid exchange apparatus and methods
First Claim
1. An exchange device to inject a therapeutic agent into an ocular implant that is at least partially implanted in an eye, the exchange device comprising:
- a connector configured to reversibly couple to a syringe;
a needle having a proximal end region fixedly coupled to the connector, the needle defining an injection lumen configured for injecting a therapeutic agent into the ocular implant through a distal opening of the needle;
a receiver container coupled to the connector; and
an outer sheath coupled to a distal end region of the receiver container, the outer sheath comprising;
a wall defining an outlet lumen between an inner diameter of the wall and an outer diameter of the needle, the outlet lumen in fluid communication with the receiver container;
a distal tip; and
a plurality of openings extending through the wall of the outer sheath into the outlet lumen,wherein the receiver container is fixedly coupled to the connector such that the outer sheath is positioned around at least a portion of the needle and the distal opening of the needle is positioned distal to the distal tip of the outer sheath, andwherein application of positive pressure through the injection lumen by the syringe during injection of the therapeutic agent into the ocular implant displaces, with at least partial separation from the injected therapeutic agent, pre-existing liquid in the ocular implant into the receiver container via the outlet lumen.
2 Assignments
0 Petitions
Accused Products
Abstract
An injector apparatus comprises an elongate structure having one or more openings positionable near a penetrable barrier of an implantable device so as to receive fluid of the implantable device. The apparatus comprises a needle and a sheath extending over at least a portion of the needle. The elongate structure may comprise a distal tip to penetrate tissue and the penetrable barrier, and a distal opening near the tip to release therapeutic fluid into the implantable chamber. In many embodiments the distal tip, the distal opening, and the plurality of openings are separated from a stop that engages a tissue of the patient and limit penetration depth such that the distal opening and the plurality of openings are located along an axis of the implantable device to increase an efficiency of the exchange.
-
Citations
20 Claims
-
1. An exchange device to inject a therapeutic agent into an ocular implant that is at least partially implanted in an eye, the exchange device comprising:
-
a connector configured to reversibly couple to a syringe; a needle having a proximal end region fixedly coupled to the connector, the needle defining an injection lumen configured for injecting a therapeutic agent into the ocular implant through a distal opening of the needle; a receiver container coupled to the connector; and an outer sheath coupled to a distal end region of the receiver container, the outer sheath comprising; a wall defining an outlet lumen between an inner diameter of the wall and an outer diameter of the needle, the outlet lumen in fluid communication with the receiver container; a distal tip; and a plurality of openings extending through the wall of the outer sheath into the outlet lumen, wherein the receiver container is fixedly coupled to the connector such that the outer sheath is positioned around at least a portion of the needle and the distal opening of the needle is positioned distal to the distal tip of the outer sheath, and wherein application of positive pressure through the injection lumen by the syringe during injection of the therapeutic agent into the ocular implant displaces, with at least partial separation from the injected therapeutic agent, pre-existing liquid in the ocular implant into the receiver container via the outlet lumen. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
-
Specification